Geodesic
Satellite DNA and chromosome translocations: a hypothesis regarding «Robertsonian» chromosome formation
Atti della Accademia nazionale dei Lincei. Rendiconti della Classe di scienze fisiche, matematiche e naturali, Série 8, Tome 83 (1989) no. 1, pp. 319-326.

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A hypothesis is presented concerning the formation of «Robertsonian» metacentrics, i.e. whole chromosomal arm translocations. During DNA-synthesis the base pairing of homologous parental strands, carried by different chromosomes, produces heteroduplexes. The rearranged DNA region would then be cut off by topoisomerases, and two acrocentric chromosomes would be fused into one metacentric. The analysis of the structure of the genome of different animal groups such as Muridae, Bovidae and Primates, supports the idea that chromosomes can exchange parts, or whole arms, in sites where base sequences show a high degree of homology.
La fusione Robertsoniana (Rb) di cromosomi acrocentrici è uno degli eventi più frequenti capaci di diversificare il cariotipo. Ciononostante il meccanismo molecolare di tale evento non è ancora chiaro. Nella presente Nota viene suggerita l'ipotesi che, durante la sintesi del DNA, l'appaiamento di basi di sequenze omologhe su filamenti parentali 5' e 3' (di due diversi cromosomi le cui coordinate polari siano anti-rotate) porti alla formazione di un eteroduplex. Il taglio e la chiusura della regione di DNA riordinata (da parte di una topoisomerasi) unirebbe in un metacentrico i due cromosomi acrocentrici. L'analisi della organizzazione del genoma in relazione alla struttura del cariotipo in diversi gruppi animali da sostegno alla idea che i cromosomi possano scambiarsi parti, o intere braccia, in siti ove la sequenza di basi mostri un alto grado di omologia. 
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Redi, Carlo Alberto; Garagna, Silvia; Capanna, Ernesto. Satellite DNA and chromosome translocations: a hypothesis regarding «Robertsonian» chromosome formation. Atti della Accademia nazionale dei Lincei. Rendiconti della Classe di scienze fisiche, matematiche e naturali, Série 8, Tome 83 (1989) no. 1, pp. 319-326. http://geodesic.mathdoc.fr/item/RLINA_1989_8_83_1_a45/

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