Nitric oxide transport in carotid bifurcation after different stent interventions: a numerical study

Zhenmin Fan¹ ; Jialiang Yao¹ ; Jianda Xu² ; Xiao Liu^3, 4 ; Mingyuan Liu⁵ ; Xia Ye¹ ; Xiaoyan Deng³

¹ School of Mechanical Engineering, Jiangsu University of Technology, Changzhou Jiangsu, China
² Department of Orthopaedics, Changzhou Traditional Chinese Medical Hospital, Affiliated to Nanjing University of Traditional Chinese Medicine, 25 North Heping Road, Changzhou 213000, Jiangsu Province, China
³ Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, PR China
⁴ School of Biological Science and Medical Engineering, Beihang University, Beijing, China
⁵ Department of Vascular Surgery, Beijing Friendship Hospital, Capital Medical University; Beijing Center of Vascular Surgery, Beijing, 100050, PR China

Mathematical modelling of natural phenomena, Tome 19 (2024), article no. 7.

Résumé

Stent restenosis and late thrombosis compromise endovascular stent implantation clinical benefit, and the mechanism is unclear. Since nitric oxide (NO) plays a pivotal role in maintaining vascular homeostasis, we believe that stenting can affect NO concentration in the host artery, thereby contributing to postoperative adverse events. We numerically investigated NO concentration after stenting based on the patient-specific carotid to verify this hypothesis. The simulation revealed that stent implantation caused blood flow disturbance, a low wall shear stress, and a significant decrease in NO on the luminal surface, especially in the region of the stented segment. Moreover, severe damage to the artery wall or low blood flow, leading to a low NO generation rate, would induce relatively low NO level in the stented segment. Additionally, we demonstrated that NO distribution might be affected by the combination of stent struts and carotid bifurcation geometry, while the host arterial configuration might play a leading role in the distribution of NO concentration. In conclusion, the carotid artery had a relatively low NO concentration level near stent struts, especially at the severely injured artery, low blood flow, long stenting, and complex host artery which might lead to a genesis/development of adverse events after that intervention.

Détail

DOI : 10.1051/mmnp/2023039

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