Stability and conductivity of bilayer lipid membrane in presence $\mathrm{Al_2O_3}$ nanoparticles
Proceedings of the Yerevan State University. Physical and mathematical sciences, Tome 57 (2023) no. 1, pp. 23-30.

Voir la notice de l'article provenant de la source Math-Net.Ru

The effect of aluminum oxide nanoparticles $\mathrm{(Al_2O_3)}$ on the stability and conductivity of BLM (the bilayer lipid membrane) in solution was studied. It has been shown that $\mathrm{Al_2O_3}$ nanoparticles increase the stability of BLM in an electric field, and BLM becomes more stable with increasing their concentration. The experimental data are analyzed in terms of the well-known theory of BLM stability, which is based on the concept of spontaneous formation of microscopic pores on the BLM, the development of which leads to the loss of BLM stability. It is shown that aluminum oxide nanoparticles increase the value of the coefficient of linear tension of the pore edge, and with an increase in the concentration of nanoparticles, the linear tension also increases. It has been shown that the presence of nanoparticles in the solution leads to a decrease in BLM conductivity.
Keywords: aluminum oxide nanoparticles, stability and conductivity of BLM.
@article{UZERU_2023_57_1_a2,
     author = {Ts. M. Jomardyan and G. V. Ananyan and V. B. Arakelyan},
     title = {Stability  and  conductivity  of  bilayer  lipid  membrane in  presence $\mathrm{Al_2O_3}$  nanoparticles},
     journal = {Proceedings of the Yerevan State University. Physical and mathematical sciences},
     pages = {23--30},
     publisher = {mathdoc},
     volume = {57},
     number = {1},
     year = {2023},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/UZERU_2023_57_1_a2/}
}
TY  - JOUR
AU  - Ts. M. Jomardyan
AU  - G. V. Ananyan
AU  - V. B. Arakelyan
TI  - Stability  and  conductivity  of  bilayer  lipid  membrane in  presence $\mathrm{Al_2O_3}$  nanoparticles
JO  - Proceedings of the Yerevan State University. Physical and mathematical sciences
PY  - 2023
SP  - 23
EP  - 30
VL  - 57
IS  - 1
PB  - mathdoc
UR  - http://geodesic.mathdoc.fr/item/UZERU_2023_57_1_a2/
LA  - en
ID  - UZERU_2023_57_1_a2
ER  - 
%0 Journal Article
%A Ts. M. Jomardyan
%A G. V. Ananyan
%A V. B. Arakelyan
%T Stability  and  conductivity  of  bilayer  lipid  membrane in  presence $\mathrm{Al_2O_3}$  nanoparticles
%J Proceedings of the Yerevan State University. Physical and mathematical sciences
%D 2023
%P 23-30
%V 57
%N 1
%I mathdoc
%U http://geodesic.mathdoc.fr/item/UZERU_2023_57_1_a2/
%G en
%F UZERU_2023_57_1_a2
Ts. M. Jomardyan; G. V. Ananyan; V. B. Arakelyan. Stability  and  conductivity  of  bilayer  lipid  membrane in  presence $\mathrm{Al_2O_3}$  nanoparticles. Proceedings of the Yerevan State University. Physical and mathematical sciences, Tome 57 (2023) no. 1, pp. 23-30. http://geodesic.mathdoc.fr/item/UZERU_2023_57_1_a2/

[1] E. I. Syrma, “Physical Properties of Nanoparticles and Their Biological Effects”, Integrative Anthropology, 1:21 (2013), 30—35 (in Russian)

[2] G. B. Andreev, V. M. Minashkin, et al., “Materials Produced by Nanotechnologies: Potential Risk in Obtaining and Using”, J. Russian Chemical Society Named After D.I. Mendeleev, LII:5 (2008), 32–38 (in Russian)

[3] O. Bondarenko, K. Juganson, A. Ivask, “Toxicity of Ag, CuO and ZnO Nanoparticles to Selected Environmentally Relevant Test Organisms and Mammalian Cells $in~vitro$: A Critical Review”, J. Archives of Toxicology, 87:7 (2013), 1181–1200 | DOI

[4] S. Böhme, H. Stärk, et al., “Quantification of Al$_2$O$_3$ Nanoparticles in Human Cell Lines Applying Inductively Coupled Plasma Mass Spectrometry (neb-ICP-MS, LA-ICP-MS) and Flow Cytometry-based Methods”, J. Nanopart. Res., 16 (2014) | DOI | MR

[5] A.P. Sarapultsev, C.V. Rempel, et al., “Interaction of Nanoparticles with Biological Objects”, Bulletin of the Ural Medical Academic Science, 3 (2016), 97–110 (in Russian) | DOI

[6] V. G. Ivkov, G. N. Berestovsky, Lipid Bilayer of Biological Membranes, Science, Moscow, 1985, 224 pp. (in Russian)

[7] N. V. Zaitseva, M. A. Zemlyanova, et al., “Evaluation of Toxicity and Potential Hazard of Aluminum Oxide Nanoparticles for Human Health”, Human Ecology, 2018, no. 5, 9–15 (in Russian) | DOI

[8] P. Mueller et al., “Methods for the Formation of Single Bimolecular Lipid Membranes in Aqueous Solution”, J. Phys. Chem., 67:2 (1963), 534–535 | DOI

[9] I.G. Abidor, V.B. Arakelian, V.F. Pastushenko, M.R. Tarasevich, L.V. Chernomordik, Yu.A. Chizmadzhev, “Electric Breakdown of Bilayer Lipid Membranes: I–VII”, Bioelectrochem. Bioenerg., 6 (1979), 37–104 | DOI

[10] G. B. Melikyan, N. S. Matinyan, V. B. Arakelian, “The Influence of Gangliosides on the Hydrophilic Pore Edge Line Tension and Monolayer Fusion of Lipid Membranes”, Biochim. Biophys. Acta, 1030 (1990), 11–15 | DOI

[11] A. L. Torosyan, V. B. Arakelyan, “Influence of H2TOEtPyP4 Porphyrin on the Stability and Conductivity of Bilayer Lipid Membranes”, European Biophysics Journal, 44:8 (2015), 745–750 | DOI

[12] V. G. Ivkov, G. N. Berestovsky, Dynamic Structure of the Lipid Bilayer, Science, Moscow, 1981, 224 pp. (in Russian)

[13] L. V. Chernomordik, M. M. Kozlov, et al., “Shape of Lipid Molecules and Monolayer Membrane Fusion”, Biological Membranes, 1:4 (1984), 411–427 (in Russian)

[14] A. V. Sokolov, Study of the Effects of Products of the Visual Cycle on Bilayer Lipid Membranes, Ph.D. Thesis, Moscow, 2009, 23 pp. (in Russian)

[15] Yu. A. Chizmadzhev, L. V. Chernomordik, et al., “Electrical Breakdown of Bilayer Lipid Membranes. Results of Science and Technology”, Biophysics of Membranes, v. 2, 1982, 161–266 (in Russian) | MR

[16] V. S. Markin, M. M. Kozlov, “The Pore Statistics in Bilayer Lipid Membranes”, Journal Biological Membranes, 2:2 (1985), 205—222 (in Russian)

[17] S. Ghosh, H. Mashayekhi, et al., “Colloidal Behavior of Aluminum Oxide Nanoparticles as Affected by pH and Natural Organic Matter”, Langmuir, 24 (2008), 12385–12391 | DOI

[18] J. Mui, J. Ngo, B. Kim, “Aggregation and Colloidal Stability of Commercially Available Al$_2$O$_3$ Nanoparticles in Aqueous Environments”, Nanomaterials, 6 (2016), 90–104 | DOI

[19] U. Pedersen, C. Leidy, et al., “The Effect of Calcium on the Properties of Charged Phospholipid Bilayers”, Biochimica et Biophysica Acta (BBA) Biomembranes, 1758:5 (2006), 573–582 | DOI

[20] E. V. Shevchenko, V. F. Antonov, “Influence of Divalent Ions on Physical Properties of Bilayer Lipid Membranes from Zwitterionic and Acidic Phospholipids”, Siberian Medical Journal, 3:2 (1995), 5–8 (in Russian) | MR