Geodesic
Effect of ligand binding on functionality of DNA field-effect transistor
Proceedings of the Yerevan State University. Physical and mathematical sciences, Tome 51 (2017) no. 1, pp. 66-70

Voir la notice de l'article provenant de la source Math-Net.Ru

Motivated by the prospects of developing DNA field-effect transistors, as tools for a variety of application fields such as medical diagnostics, environmental pollutants monitoring, biological weapons defense, and taking into account that the efficiency of DNA-sensors depends on the precise prediction of experimental parameters responsible for thermostability of nucleic acids duplexes and specific times of formation of DNA duplexes, we analyze the factors influencing both the thermodynamics of hybridization and the stability of DNA–DNA and DNA–RNA duplexes. In this work the case of competition-free DNA hybridization is analyzed. It is shown how the intercalating ligands effectively increase the binding constant for the target sequences and thus affects the sensitivity of the DNA-chip.
Keywords: ligand binding, thermostability, hybridization, DNA-chip. 
@article{UZERU_2017_51_1_a11,
     author = {E. Sh. Mamasakhlisov and A. P. Antonyan and A. A. Akopyan},
     title = {Effect of ligand binding on functionality of {DNA} field-effect transistor},
     journal = {Proceedings of the Yerevan State University. Physical and mathematical sciences},
     pages = {66--70},
     publisher = {mathdoc},
     volume = {51},
     number = {1},
     year = {2017},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/UZERU_2017_51_1_a11/}
}
TY  - JOUR
AU  - E. Sh. Mamasakhlisov
AU  - A. P. Antonyan
AU  - A. A. Akopyan
TI  - Effect of ligand binding on functionality of DNA field-effect transistor
JO  - Proceedings of the Yerevan State University. Physical and mathematical sciences
PY  - 2017
SP  - 66
EP  - 70
VL  - 51
IS  - 1
PB  - mathdoc
UR  - http://geodesic.mathdoc.fr/item/UZERU_2017_51_1_a11/
LA  - en
ID  - UZERU_2017_51_1_a11
ER  - 
%0 Journal Article
%A E. Sh. Mamasakhlisov
%A A. P. Antonyan
%A A. A. Akopyan
%T Effect of ligand binding on functionality of DNA field-effect transistor
%J Proceedings of the Yerevan State University. Physical and mathematical sciences
%D 2017
%P 66-70
%V 51
%N 1
%I mathdoc
%U http://geodesic.mathdoc.fr/item/UZERU_2017_51_1_a11/
%G en
%F UZERU_2017_51_1_a11
E. Sh. Mamasakhlisov; A. P. Antonyan; A. A. Akopyan. Effect of ligand binding on functionality of DNA field-effect transistor. Proceedings of the Yerevan State University. Physical and mathematical sciences, Tome 51 (2017) no. 1, pp. 66-70. http://geodesic.mathdoc.fr/item/UZERU_2017_51_1_a11/