Geodesic
Mitoxantrone interaction with $\mathrm{poly(G)}$
Proceedings of the Yerevan State University. Physical and mathematical sciences, no. 3 (2015), pp. 49-54

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In the present work the thermodynamic studies of mitoxantrone complexformation with four-stranded $\mathrm{poly(G)}$ have been carried out. The binding thermodynamic parameters, the binding constant $K$ and the number of nucleotides corresponding to one binding site $n$, were determined. It was shown that mitoxantrone is bound stronger with four-stranded $\mathrm{poly(G)}$, then it is bound with double-stranded helix. It was also shown that due to difficulties of the intercalation of mitoxantrone molecules into four-stranded structure is bound mainly by external binding mode with $[\mathrm{poly(G)}]_4$ and at the interaction saturation mitoxantrone bound to much more guanines ($n\cong10$) per one molecule.
Keywords: four-stranded structure, $[\mathrm{poly(G)}]_4$, absorption spectrum, thermodynamic binding parameters.
Mots-clés : mitoxantrone, complex-formation 
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A. T. Karapetyan; Yu. S. Babayan; M. A. Torosyan; M. A. Shahinyan. Mitoxantrone interaction with $\mathrm{poly(G)}$. Proceedings of the Yerevan State University. Physical and mathematical sciences, no. 3 (2015), pp. 49-54. http://geodesic.mathdoc.fr/item/UZERU_2015_3_a7/