Geodesic
The interaction of $\mathrm{Аg}$-containing porphyrins with DNA at high ionic strength
Proceedings of the Yerevan State University. Physical and mathematical sciences, no. 2 (2009), pp. 55-59 Cet article a éte moissonné depuis la source Math-Net.Ru

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UV-VIS spectrophotometry and circular dichroism (CD) methods were applied to study the binding of DNA with three novel $\mathrm{Аg}$-containing porphyrins meso-tetra($4N$-allylpyridyl) $(\mathrm{AgTAlPyP4})$, meso-tetra($4$N-butylpyridyl) $(\mathrm{AgTButPyP4})$ and meso-tetra($4N$-oxyethylpyridyl) $(\mathrm{AgTOEtPyP4})$ at high ionic strength. The binding constant $K_b$ and stoichiometry n were determined from binding isotherms for each ligand–DNA complex. The Gibbs free energy, enthalpy and entropy of binding also were calculated using the values of Kb. Obtained results show that these porphyrins associate with the duplex DNA via outside binding mode.
Keywords: DNA, porphyrin, ionic strength. 
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     title = {The interaction of $\mathrm{{\CYRA}g}$-containing porphyrins with {DNA} at high ionic strength},
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S. A. Sulyman; A. A. Ghazaryan; Y. B. Dalyan. The interaction of $\mathrm{Аg}$-containing porphyrins with DNA at high ionic strength. Proceedings of the Yerevan State University. Physical and mathematical sciences, no. 2 (2009), pp. 55-59. http://geodesic.mathdoc.fr/item/UZERU_2009_2_a9/

[1] M.G. Vicente, “Porphyrin-based sensitizers in the detection and treatment of cancer: recent progress”, Curr. Med. Chem. Anti-Cancer Agents, 1 (2001), 175–194 | DOI

[2] L.G. Marzilli, “Medical aspects of DNA-porphyrin interactions”, New J. of Chem., 14 (1990), 409–420

[3] R.F. Pasternack, E.J. Gibbs, “Porphyrin and metalloporphyrin interactions with nucleic acids”, Metal Ions in Biological Systems, eds. Sigel A., Sigel H., Marcel Dekker, NY, 1996, 367–397

[4] R.F. Pasternack, E.J. Gibbs, J.J. Villafranca, “Interactions of Porphyrins with Nucleic Acids”, Biochemistry, 22 (1983), 5409–5417 | DOI

[5] R. Kuroda, H. Tanaka, “DNA–porphyrin interactions probed by induced CD spectroscopy”, J. Chem. Soc., Chem. Commun., 1994, 1575–1576 | DOI

[6] R.F. Pasternack, “Circular Dichroism and the Interactions of Water Soluble Porphyrins with DNA”, Chirality, 15 (2003), 329–332 | DOI

[7] A.S. Saffaa Aldeen, Vestnik IAELPS, 13:4 (2008), 75–78

[8] S. Haroutiunian, Y. Dalyan, A. Ghazaryan, T. Chalikian, “Thermodynamic profile of interaction of porphyrins with nucleic acids”, Brilliant Light in Life and Material Sciences, eds. V. Tsakanov, H. Wiedemann, Springer, 2007, 213–218 | DOI

[9] V.N. Madakyan, R.K. Kazaryan, M.A. Khachatryan, A.S. Stepanyan, T.S. Kurtikyan, M.B. Ordyan, “New derivatives of meso-(tetra-4-pyridyl)porphine and their reactions”, Chim. Heterosikl. Soed., 2 (1986), 212–216 (in Russian)

[10] J.J. Correia, J.B. Chaires, “Analysis of drug-DNA Binding Isotherms: a Monte Carlo Approach”, Methods in Enzymology, 240 (1994), 593–614 | DOI