Geodesic
Theoretical Hyperbolic Model of a Partial Agonism: Explicit Formulas for Affinity, Efficacy and Amplification
Serdica Journal of Computing, Tome 5 (2011) no. 4, pp. 333-358

Voir la notice de l'article provenant de la source Bulgarian Digital Mathematics Library

The quantitative analysis of receptor-mediated effect is based on experimental concentration-response data in which the independent variable, the concentration of a receptor ligand, is linked with a dependent variable, the biological response. The steps between the drug–receptor interaction and the subsequent biological effect are to some extent unknown. The shape of the fitting curve of the experimental data may give some in-sights into the nature of the concentration–receptor–response (C-R-R) mechanism. It can be evaluated by non-linear regression analysis of the experimental data points of the independent and dependent variables, which could be considered as a history of the interaction between the drug and receptors. However, this information is not enough to evaluate such important parameters of the mechanism as the dissociation constant (affinity) and efficacy. There are two ways to provide more detailed information about the C-R-R mechanism: (i) an experimental way for obtaining data with new or
Keywords: Model, Agonist, Affinity, Efficacy, Amplification, Receptor 
@article{SJC_2011_5_4_a2,
     author = {Milanov, Peter and Pencheva, Nevena},
     title = {Theoretical {Hyperbolic} {Model} of a {Partial} {Agonism:} {Explicit} {Formulas} for {Affinity,} {Efficacy} and {Amplification}},
     journal = {Serdica Journal of Computing},
     pages = {333--358},
     publisher = {mathdoc},
     volume = {5},
     number = {4},
     year = {2011},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/SJC_2011_5_4_a2/}
}
TY  - JOUR
AU  - Milanov, Peter
AU  - Pencheva, Nevena
TI  - Theoretical Hyperbolic Model of a Partial Agonism: Explicit Formulas for Affinity, Efficacy and Amplification
JO  - Serdica Journal of Computing
PY  - 2011
SP  - 333
EP  - 358
VL  - 5
IS  - 4
PB  - mathdoc
UR  - http://geodesic.mathdoc.fr/item/SJC_2011_5_4_a2/
LA  - en
ID  - SJC_2011_5_4_a2
ER  - 
%0 Journal Article
%A Milanov, Peter
%A Pencheva, Nevena
%T Theoretical Hyperbolic Model of a Partial Agonism: Explicit Formulas for Affinity, Efficacy and Amplification
%J Serdica Journal of Computing
%D 2011
%P 333-358
%V 5
%N 4
%I mathdoc
%U http://geodesic.mathdoc.fr/item/SJC_2011_5_4_a2/
%G en
%F SJC_2011_5_4_a2
Milanov, Peter; Pencheva, Nevena. Theoretical Hyperbolic Model of a Partial Agonism: Explicit Formulas for Affinity, Efficacy and Amplification. Serdica Journal of Computing, Tome 5 (2011) no. 4, pp. 333-358. http://geodesic.mathdoc.fr/item/SJC_2011_5_4_a2/