Mathematical and numerical models of two asymmetric gene networks

V. P. Golubyatnikov ; M. V. Kazantsev ; N. E. Kirillova ; T. A. Bukharina

Sibirskie èlektronnye matematičeskie izvestiâ, Tome 15 (2018), pp. 1271-1283.

Résumé

We construct and study mathematical models of two gene networks: a circular gene network of molecular repressilator, and a natural gene network which does not have circular structure. For the first model, we consider discretization of phase portrait of corresponding nonlinear dynamical system and find conditions of existence of an oscillating trajectory (cycle) in this phase portrait. The second model describes the central regulatory circuit of one gene network which acts on early stage of the fruit fly Drosophila melanogaster mechanoreceptors morphogenesis. For both models we give biological interpretations of our numerical simulations and give a short description of software elaborated specially for these experiments.

Détail

Keywords: nonlinear dynamical systems, gene networks models, hyperbolic equilibrium points, Grobman-Hartman theorem, Brouwer fixed point theorem, numerical analysis.
Mots-clés : cycles, phase portraits

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