Molecular structure and anti-fungicidal properties of coatings based on clotrimazole and polymers formed from the active gas phase

M. A. Yarmolenko ; Jiang Xiao Homg ; A. A. Rogachev ; A. V. Rogachev ; A. S. Rudenkov ; O. A. Yarmolenko ; S. A. Frolov

Problemy fiziki, matematiki i tehniki, no. 1 (2024), pp. 50-56.

Résumé

The features of the molecular structure, chemical composition and antifungicidal properties of the coatings based on clotrimazole, polyurethane (PU), polyvinyl chloride (PVC), formed from the active gas phase formed by electron beam dispersion of compounds in a vacuum, were determined. It was found that the chemical composition of the clotrimazole-based coating almost completely corresponds to the chemical composition of the original drug compound. A slight decrease in chlorine in the coating compared to the original drug compound is explained by the partial destruction of C – Cl bonds under the influence of an electron flow. The high efficiency of regulating the prolonged release of a drug compound by forming composite coatings has been established. It has been shown that the fungicidal activity of composite coatings is largely determined by the properties of the polymer matrix. The coatings based on clotrimazole and graphitized PVC exhibit higher activity.

Détail

Keywords: electron beam dispersion, coating, clotrimazole, polyurethane, polyvinyl chloride, molecular structure, properties.

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