Geodesic
Optimal partitioning method for evaluating of effect of hemoglobin oxygenation levels of vessel endothelial growth factor
Matematičeskaâ biologiâ i bioinformatika, Tome 13 (2018) no. 2, pp. 563-590 
O. V. Senko; M. S. Kodryan; A. V. Kuznetsova; L. L. Klimenko; A. I. Deev; I. S. Baskakov; A. N. Mazilina. Optimal partitioning method for evaluating of effect of hemoglobin oxygenation levels of vessel endothelial growth factor. Matematičeskaâ biologiâ i bioinformatika, Tome 13 (2018) no. 2, pp. 563-590. http://geodesic.mathdoc.fr/item/MBB_2018_13_2_a5/
@article{MBB_2018_13_2_a5,
     author = {O. V. Senko and M. S. Kodryan and A. V. Kuznetsova and L. L. Klimenko and A. I. Deev and I. S. Baskakov and A. N. Mazilina},
     title = {Optimal partitioning method for evaluating of effect of hemoglobin oxygenation levels of vessel endothelial growth factor},
     journal = {Matemati\v{c}eska\^a biologi\^a i bioinformatika},
     pages = {563--590},
     year = {2018},
     volume = {13},
     number = {2},
     language = {ru},
     url = {http://geodesic.mathdoc.fr/item/MBB_2018_13_2_a5/}
}
TY  - JOUR
AU  - O. V. Senko
AU  - M. S. Kodryan
AU  - A. V. Kuznetsova
AU  - L. L. Klimenko
AU  - A. I. Deev
AU  - I. S. Baskakov
AU  - A. N. Mazilina
TI  - Optimal partitioning method for evaluating of effect of hemoglobin oxygenation levels of vessel endothelial growth factor
JO  - Matematičeskaâ biologiâ i bioinformatika
PY  - 2018
SP  - 563
EP  - 590
VL  - 13
IS  - 2
UR  - http://geodesic.mathdoc.fr/item/MBB_2018_13_2_a5/
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%0 Journal Article
%A O. V. Senko
%A M. S. Kodryan
%A A. V. Kuznetsova
%A L. L. Klimenko
%A A. I. Deev
%A I. S. Baskakov
%A A. N. Mazilina
%T Optimal partitioning method for evaluating of effect of hemoglobin oxygenation levels of vessel endothelial growth factor
%J Matematičeskaâ biologiâ i bioinformatika
%D 2018
%P 563-590
%V 13
%N 2
%U http://geodesic.mathdoc.fr/item/MBB_2018_13_2_a5/
%G ru
%F MBB_2018_13_2_a5

Voir la notice de l'article provenant de la source Math-Net.Ru

The work is aimed to study relationship between vessel endothelial growth factor (VEGF) serum levels and hypoxia in patients with severe neurological disorders. Overviewed literature sources indicate activation of VEGF synthesis during hypoxia. But standard correlation analysis does not reveal a statistically significant association between VEGF levels and pulse oxymetry parameters objectively assessing oxygen supply. Due to a proposed in the paper technique it became possible to reveal valid relationship between VEGF levels and oxygenation. This relationship can be described as increase of correlation between VEGF and immunological complement C4 when oxygenation level is below a certain threshold. Developed method includes searching of such boundaries for oxymetry parameters that correlation coefficients between VEGF and some additional factor Z in formed group are maximally different. ranges. The original technique based on permutation test was used not only to asses validity of effects associated with each oxymetry parameter but also to evaluate joint effect by full group of such factors. Great number of variable from database were tested as additional factors/ So additional correction of validity was made to take into account multiple testing.

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