Modeling of human breath: conceptual and mathematical statements
Matematičeskaâ biologiâ i bioinformatika, Tome 11 (2016) no. 1, pp. 64-80.

Voir la notice de l'article provenant de la source Math-Net.Ru

The article is devoted to the main aspects of the development of a mathematical model of the human respiratory system taking into account the effects of environmental factors. The proposed model is a submodel of "meso-level" multilayered mathematical model of the evolution of functional disorders of the human body. The conceptual and mathematical formulations of the problem are discussed. The breathing is considered as a set of synchronized processes of gas dynamics, deformation of the porous medium and diffusion. The results of the calculation of the air flow characteristics during quiet breathing and forced breath in the first four generations of large airways were obtained by using software ANSYS Fluent. Further development of the model involves the joint problem solving of changes in lung configuration and in gasdynamic processes in the human airway.
@article{MBB_2016_11_1_a4,
     author = {P. V. Trusov and N. V. Zaitseva and M. Yu. Tsinker},
     title = {Modeling of human breath: conceptual and mathematical statements},
     journal = {Matemati\v{c}eska\^a biologi\^a i bioinformatika},
     pages = {64--80},
     publisher = {mathdoc},
     volume = {11},
     number = {1},
     year = {2016},
     language = {ru},
     url = {http://geodesic.mathdoc.fr/item/MBB_2016_11_1_a4/}
}
TY  - JOUR
AU  - P. V. Trusov
AU  - N. V. Zaitseva
AU  - M. Yu. Tsinker
TI  - Modeling of human breath: conceptual and mathematical statements
JO  - Matematičeskaâ biologiâ i bioinformatika
PY  - 2016
SP  - 64
EP  - 80
VL  - 11
IS  - 1
PB  - mathdoc
UR  - http://geodesic.mathdoc.fr/item/MBB_2016_11_1_a4/
LA  - ru
ID  - MBB_2016_11_1_a4
ER  - 
%0 Journal Article
%A P. V. Trusov
%A N. V. Zaitseva
%A M. Yu. Tsinker
%T Modeling of human breath: conceptual and mathematical statements
%J Matematičeskaâ biologiâ i bioinformatika
%D 2016
%P 64-80
%V 11
%N 1
%I mathdoc
%U http://geodesic.mathdoc.fr/item/MBB_2016_11_1_a4/
%G ru
%F MBB_2016_11_1_a4
P. V. Trusov; N. V. Zaitseva; M. Yu. Tsinker. Modeling of human breath: conceptual and mathematical statements. Matematičeskaâ biologiâ i bioinformatika, Tome 11 (2016) no. 1, pp. 64-80. http://geodesic.mathdoc.fr/item/MBB_2016_11_1_a4/

[1] Shklyar B. S., Diagnostika vnutrennikh boleznei, Vysshaya shkola, Kiev, 1972, 516 pp.

[2] Grebenev A. L., Propedevtika vnutrennikh boleznei, Meditsina, M., 2001, 592 pp.

[3] Trusov P. V., Zaitseva N. V., Kiryanov D. A., Kamaltdinov M. R., Tsinker M. Yu., Chigvintsev V. M., Lanin D. V., “Matematicheskaya model evolyutsii funktsionalnykh narushenii v organizme cheloveka s uchetom vneshnesredovykh faktorov”, Matematicheskaya biologiya i bioinformatika, 7:2 (2012), 589–610 | DOI

[4] Zaitseva N. V., Trusov P. V., Shur P. Z., Kiryanov D. A., Chigvintsev V. M., Tsinker M. Yu., “Metodicheskie podkhody k otsenke riska vozdeistviya raznorodnykh faktorov sredy obitaniya na zdorove naseleniya na osnove evolyutsionnykh modelei”, Analiz riska zdorovyu, 2013, no. 1, 15–23

[5] Tsinker M. Yu., “Dykhanie cheloveka kak biomekhanicheskii protsess”, Matematicheskoe modelirovanie v estestvennykh naukakh, Materialy XXIII Vserossiiskoi shkoly-konferentsii molodykh uchenykh i studentov, v. 1, Izd-vo PNIPU, Perm, 2014, 290–292

[6] Tsinker M. Yu., “Matematicheskaya model dykhatelnoi sistemy cheloveka”, Biomekhanika-2014, Materialy XI Vserossiiskoi konferentsii s mezhdunarodnym uchastiem i shkoly-seminara dlya molodykh uchenykh (Perm, 1–4 dekabrya 2014), Izd-vo PNIPU, Perm, 2014, 255–258

[7] Onischenko G. G., Zaitseva N. V., Zemlyanova M. A., Gigienicheskaya indikatsiya posledstvii dlya zdorovya pri vneshnesredovoi ekspozitsii khimicheskikh faktorov, ed. Onischenko G. G., Knizhnyi format, Perm, 2011, 532 pp.

[8] Zaitseva N. V., Ustinova O. Yu., Aminova A. I., Gigienicheskie aspekty narusheniya zdorovya detei pri vozdeistvii khimicheskikh faktorov sredy obitaniya, ed. Zaitseva N. V., Knizhnyi format, Perm, 2011, 489 pp.

[9] Lyubimov G. A., “Modeli legkikh cheloveka i issledovanie s ikh pomoschyu mekhaniki dykhaniya”, Trudy matematicheskogo instituta im. V. A. Steklova, 223, 1998, 196–206 | Zbl

[10] Ben-Tal A., “Simplified models for gas exchange in the human lungs”, Journal of Theoretical Biology, 238 (2006), 474–495 | DOI

[11] Benallal H., Beck K. C., Johnson B. D., Busso T., “Evaluation of cardiac output from a tidally ventilated homogeneous lung model”, Eur. J. Appl. Physiol., 95 (2005), 153–162 | DOI

[12] Kuwahara F., Sano Y., Liu J., Nakayama A., “A Porous Media Approach for Bifurcating Flow and Mass Transfer in a Human Lung”, J. Heat Transfer., 131:10 (2009) | DOI

[13] Reis A. H., Miguel A. F., Aydin M., “Constructal theory of flow architecture of the lungs”, Journal of Medical Physics, 31 (2004), 1135–1140 | DOI

[14] Kirillova I. V., Gramakova A. A., Belova Yu. A., Chelnokova N. O., “Trekhmernoe modelirovanie trakheobronkhialnogo dereva”, Metody kompyuternoi diagnostiki v biologii i meditsine-2009, Materialy ezhegodnoi Vserossiiskoi nauchnoi shkoly-seminara, ed. Usanov D. A., Izdatelstvo Saratovskogo universiteta, Saratov, 2009

[15] Fomin V. M., Vetlutskii V. N., Ganimedov V. L., Muchnaya M. I., Shepelenko V. N., Melnikov M. N., Savina A. A., “Issledovanie techeniya vozdukha v nosovoi polosti cheloveka”, Prikladnaya mekhanika i tekhnicheskaya fizika, 51:2 (2010), 107–115 | MR | Zbl

[16] Fomin V. M., Ganimedov V. L., Melnikov M. N., Muchnaya M. I., Sadovskii A. S., Shepelenko V. I., “Chislennoe modelirovanie techeniya vozdukha v nosovoi polosti cheloveka s imitatsiei primeneniya klinicheskogo metoda perednei aktivnoi rinomanometrii”, Prikladnaya mekhanika i tekhnicheskaya fizika, 53:1 (2012), 58–66 | Zbl

[17] Ganimedov V. L., Muchnaya M. I., Sadovskii A. S., “Techenie vozdukha v nosovoi polosti cheloveka. Rezultaty matematicheskogo modelirovaniya”, Rossiiskii zhurnal biomekhaniki, 19:1 (2015), 37–51 | DOI

[18] Lambert A. R., Regional deposition of particles in an image-based airway model: CFD simulation and left-right lung ventilation asymmetry, MS (Master of science) thesis, University of Iowa, Iowa, 2010, 68 pp.

[19] Wall W. A., Rabczuk T., “Fluid structure interaction in lower airways of CT-based lung geometries”, Int. J. Num. Methods in fluids, 57 (2008), 653–675 | DOI | MR | Zbl

[20] Kleinstreuer C., Zhanga Z., Lia Z., Roberts W. L., Rojasc C., “A new methodology for targeting drug-aerosols in the human respiratory system”, International Journal of Heat and Mass Transfer, 51 (2008), 5578–5589 | DOI | Zbl

[21] Choi J., Multiscale numerical analysis of airflow in CT-based subject specific breathing human lungs, PhD Dissertation, University of Iowa, Iowa, 2011, 259 pp.

[22] Veibel E. R., Morfometriya legkikh cheloveka, Meditsina, M., 1970, 176 pp.

[23] Kaletina N. I. (red.), Toksikologicheskaya khimiya. Metabolizm i analiz toksikantov, Uchebnoe posobie dlya vuzov, GEOTAR-Media, M., 2008, 1016 pp.

[24] Lure A. I., Teoriya uprugosti, Nauka, M., 1970, 940 pp.

[25] Uest Dzh., Fiziologiya dykhaniya. Osnovy, Mir, M., 1988, 196 pp.

[26] Sinelnikov R. D., Sinelnikov Ya. R., Atlas anatomii cheloveka, v. 2, 2-e izdanie v 4 tomakh, Meditsina, M., 1996, 264 pp.

[27] Borzyak E. I., Volkova L. I., Dobrovolskaya E. A., Revazov V. S., Sapin M. R., Anatomiya cheloveka, v. 1, ed. Sapin M. R., Meditsina, M., 1993, 544 pp.

[28] Kukes V. G., Marinin V. F., Reutskii I. A., Sivkov S. I., Vrachebnye metody diagnostiki (osmotr, palpatsiya, perkussiya, auskultatsiya), Uchebnoe posobie dlya vuzov, GEOTAR-Media, M., 2006, 720 pp.

[29] Zolotko Yu. L., Atlas topograficheskoi anatomii cheloveka, Meditsina, M., 1967, 272 pp.

[30] Morgan E. Dzh., Megid S. M., Klinicheskaya anesteziologiya, v. 2, BINOM-Nevskii Dialekt, M.-SPb., 2001, 396 pp.