Identification of Gene Markers for Aggressive Forms of Low-Grade Glioma Using TCGA Expression Data
Matematičeskaâ biologiâ i bioinformatika, Tome 9 (2014) no. 2, pp. 527-533.

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Low-grade glioma is a group of tumors of central nervous system. Unlike other malignant subtypes such as glioblastoma multiforme, low-grade gliomas have a lower mortality. However, after initial treatment in about 40% of low-grade gliomas new tumor events are observed. In this study identification of new genes responsible for the aggressive phenotype of tumors was carried out using RNA-seq data from the The Cancer Genome Atlas (TCGA) database. It was found that 85 genes with affected expression levels were associated with new tumors after initial treatment of low-grade glioma.
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     title = {Identification of {Gene} {Markers} for {Aggressive} {Forms} of {Low-Grade} {Glioma} {Using} {TCGA} {Expression} {Data}},
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N. V. Ivanisenko; N. V. Gubanova; N. A. Kolchanov; V. A. Ivanisenko. Identification of Gene Markers for Aggressive Forms of Low-Grade Glioma Using TCGA Expression Data. Matematičeskaâ biologiâ i bioinformatika, Tome 9 (2014) no. 2, pp. 527-533. http://geodesic.mathdoc.fr/item/MBB_2014_9_2_a4/

[1] Mittler M., Walters B. C., Stopa E. G., “Observer reliability in histological grading of astrocytoma stereotactic biopsies”, J. Neumsurg., 85 (1996), 1091–1094 | DOI

[2] McLendon R., Friedman A., Bigner D., Van Meir E. G., Brat D. J., Mastrogianakis G. M., Olson J. J., Mikkelsen T., Lehman N., Yung W. K. A. et al., “Comprehensive genomic characterization defines human glioblastoma genes and core pathways”, Nature, 455 (2008), 1061–1068 | DOI

[3] Maere S., Heymans K., Kuiper M., “BiNGO: a Cytoscape plugin to assess overrepresentation of Gene Ontology categories in biological networks”, Bioinformatics, 21 (2005), 3448–3449 | DOI

[4] Smoot M. E., Ono K., Ruscheinski J., Wang P. L., Ideker T., “Cytoscape 2.8: new features for data integration and network visualization”, Bioinformatics, 27:3 (2011), 431–432 | DOI

[5] Ma Y., Ye F., Xie X., Zhou C., Lu W., “Significance of PTPRZ1 and CIN85 expression in cervical carcinoma”, Archives of gynecology and obstetrics, 284 (2011), 699–704 | DOI

[6] Lu K. V., Jong K. A., Rajasekaran A. K., Cloughesy T. F., Mischel P. S., “Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP)-2 activation and cell invasion in a human glioblastoma cell line”, Laboratory investigation, 84 (2003), 8–20

[7] Fan X., Khaki L., Zhu T. S., Soules M. E., Talsma C. E., Gu N., Koh C., Zhang J., Li Y. M., Maciaczyk J. et al., “NOTCH Pathway Blockade Depletes CD133-Positive Glioblastoma Cells and Inhibits Growth of Tumor Neurospheres and Xenografts”, Stem cells, 28:1 (2010), 5–16

[8] Fan Y., Potdar A. A., Gong Y., Eswarappa S. M., Donnola S., Lathi J. D., Hambardzumyan D., Rich J. N., Fox P. L., “Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1$\alpha$ accumulation”, Nature cell biology, 16:5 (2014), 445–456 | DOI

[9] Esposito I., Kayed H., Keleg S., Giese T., Sage E. H., Schirmacher P., Friess H., Kleeff J., “Tumor-suppressor function of SPARC-like protein 1/Hevin in pancreatic cancer”, Neoplasia, 9:1 (2007), 8–17 | DOI

[10] Donninger H., Vos M. D., Clark G. J., “The RASSF1A tumor suppressor”, Journal of cell science, 120:18 (2007), 3163–3172 | DOI

[11] Taniguchi C. M., Winnay J., Kondo T., Bronson R. T., Guimaraes A. R., Alemán J. O., Luo J., Stephanopoulos G., Weissleder R., Cantley L. C., Kahn C. R., “The phosphoinositide 3-kinase regulatory subunit p85$\alpha$ can exert tumor suppressor properties through negative regulation of growth factor signaling”, Cancer research, 70:13 (2010), 5305–5315 | DOI

[12] José-Enériz E. S., Román-Gómez J., Cordeu L., Ballestar E., Gárate L., Andreu E. J., Isidro I., Guruceaga E., Jiménez-Velasco A., Heiniger A., “BCR-ABL1-induced expression of HSPA8 promotes cell survival in chronic myeloid leukaemia”, British journal of haematology, 142:4 (2008), 571–582 | DOI

[13] Demenkov P. S., Ivanisenko T. V., Kolchanov N. A., Ivanisenko V. A., “ANDVisio: A new tool for graphic visualization and analysis of literature mined associative gene networks in the ANDSystem”, Silico Biology, 11:3 (2012), 149–161