Geodesic
Statistical Analysis of Radiation-Induced Dynamics of Cancer Cell Transcriptome Using Dna-Microarray Data
Matematičeskaâ biologiâ i bioinformatika, Tome 8 (2013), pp. 520-528.

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The DNA microarray data on radiation-induced dynamics of the transcriptome of cancer cell line HCT116 with normal and mutant gene TP53 is processed. Transcriptome is analyzed after 1, 12 and 24 hours after irradiation using the Affymetrix microarray HGU133A series. It was found that the probability characteristics of expression differences depend strongly on the intensities of the reference level, and this dependence is nonlinear in general case. We take this fact into account using the “noise envelope” algorithm in filtering, clustering and grouping. The effectiveness of the procedures can be estimated from the results of hierarchical clustering and using the method of group averages. For filtered genes, dendrograms are constructed, a preliminary comparison of gene dynamics in key signaling pathways associated with programmed cell death and DNA repair is provided. 
@article{MBB_2013_8_a7,
     author = {R. T. Sibatov and Ju. V. Saenko and V. V. Uchajkin and V. V. Saenko and E. V. Morozova and V. V. Shulezhko and E. V. Kozhemjakina and A. N. Byzykchi and G. G. Gusarov and D. A. Korobko and I. V. Jarovikova and K. V. Saltykova and I. I. Kozhemjakin and V. M. Juravlev and A. V. Juravlev and N. K. Aynullova},
     title = {Statistical {Analysis} of {Radiation-Induced} {Dynamics} of {Cancer} {Cell} {Transcriptome} {Using} {Dna-Microarray} {Data}},
     journal = {Matemati\v{c}eska\^a biologi\^a i bioinformatika},
     pages = {520--528},
     publisher = {mathdoc},
     volume = {8},
     year = {2013},
     language = {ru},
     url = {http://geodesic.mathdoc.fr/item/MBB_2013_8_a7/}
}
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AU  - Ju. V. Saenko
AU  - V. V. Uchajkin
AU  - V. V. Saenko
AU  - E. V. Morozova
AU  - V. V. Shulezhko
AU  - E. V. Kozhemjakina
AU  - A. N. Byzykchi
AU  - G. G. Gusarov
AU  - D. A. Korobko
AU  - I. V. Jarovikova
AU  - K. V. Saltykova
AU  - I. I. Kozhemjakin
AU  - V. M. Juravlev
AU  - A. V. Juravlev
AU  - N. K. Aynullova
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%A R. T. Sibatov
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%A V. V. Uchajkin
%A V. V. Saenko
%A E. V. Morozova
%A V. V. Shulezhko
%A E. V. Kozhemjakina
%A A. N. Byzykchi
%A G. G. Gusarov
%A D. A. Korobko
%A I. V. Jarovikova
%A K. V. Saltykova
%A I. I. Kozhemjakin
%A V. M. Juravlev
%A A. V. Juravlev
%A N. K. Aynullova
%T Statistical Analysis of Radiation-Induced Dynamics of Cancer Cell Transcriptome Using Dna-Microarray Data
%J Matematičeskaâ biologiâ i bioinformatika
%D 2013
%P 520-528
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R. T. Sibatov; Ju. V. Saenko; V. V. Uchajkin; V. V. Saenko; E. V. Morozova; V. V. Shulezhko; E. V. Kozhemjakina; A. N. Byzykchi; G. G. Gusarov; D. A. Korobko; I. V. Jarovikova; K. V. Saltykova; I. I. Kozhemjakin; V. M. Juravlev; A. V. Juravlev; N. K. Aynullova. Statistical Analysis of Radiation-Induced Dynamics of Cancer Cell Transcriptome Using Dna-Microarray Data. Matematičeskaâ biologiâ i bioinformatika, Tome 8 (2013), pp. 520-528. http://geodesic.mathdoc.fr/item/MBB_2013_8_a7/

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