Geodesic
Analysis of the intracellular mechanisms contribution to the action potential generation changes in excitable cell models
Matematičeskaâ biologiâ i bioinformatika, Tome 6 (2011) no. 2, pp. 200-210 
A. D. Vasilyeva; O. E. Solovyova. Analysis of the intracellular mechanisms contribution to the action potential generation changes in excitable cell models. Matematičeskaâ biologiâ i bioinformatika, Tome 6 (2011) no. 2, pp. 200-210. http://geodesic.mathdoc.fr/item/MBB_2011_6_2_a5/
@article{MBB_2011_6_2_a5,
     author = {A. D. Vasilyeva and O. E. Solovyova},
     title = {Analysis of the intracellular mechanisms contribution to the action potential generation changes in excitable cell models},
     journal = {Matemati\v{c}eska\^a biologi\^a i bioinformatika},
     pages = {200--210},
     year = {2011},
     volume = {6},
     number = {2},
     language = {ru},
     url = {http://geodesic.mathdoc.fr/item/MBB_2011_6_2_a5/}
}
TY  - JOUR
AU  - A. D. Vasilyeva
AU  - O. E. Solovyova
TI  - Analysis of the intracellular mechanisms contribution to the action potential generation changes in excitable cell models
JO  - Matematičeskaâ biologiâ i bioinformatika
PY  - 2011
SP  - 200
EP  - 210
VL  - 6
IS  - 2
UR  - http://geodesic.mathdoc.fr/item/MBB_2011_6_2_a5/
LA  - ru
ID  - MBB_2011_6_2_a5
ER  - 
%0 Journal Article
%A A. D. Vasilyeva
%A O. E. Solovyova
%T Analysis of the intracellular mechanisms contribution to the action potential generation changes in excitable cell models
%J Matematičeskaâ biologiâ i bioinformatika
%D 2011
%P 200-210
%V 6
%N 2
%U http://geodesic.mathdoc.fr/item/MBB_2011_6_2_a5/
%G ru
%F MBB_2011_6_2_a5

Voir la notice de l'article provenant de la source Math-Net.Ru

Transmembrane ion channels and exchangers are involved in forming of the excitable cell action potential (AP). When changing conditions of functioning of the cells an alters appear in the interaction of mechanisms to form AP reflecting a variation of AP shape and duration. Comparative evaluation of the effect of different cellular mechanisms on AP generation in the mathematical models became possible due to development of special methods. Using these methods we have proposed an approach that allows to analyze the causes of AP shape changes in excitable cell model as a result of various influences.

[1] Hodgkin A.L., Huxley A.F., “A quantitative description of membrane current and its application to conduction and excitation in nerve”, The Journal of Physiology, 117 (1952), 500–544

[2] Bezzina C., Veldkamp M.W., van Den Berg M.P. et al., “A single $Na^+$ channel mutation causing both long-QT and Brugada syndromes”, Circ. Res., 85 (1999), 1206–1213

[3] Abramochkin D.V., Sukhova G.S., Rozenshtraukh L.B., “Mekhanizmy funktsionirovaniya i regulyatsii sinoatrialnogo uzla mlekopitayuschikh”, Uspekhi fiziologicheskikh nauk, 40:4 (2009), 20–40

[4] Roitberg G.E., Strutynskii A.V., Vnutrennie bolezni. Serdechno-sosudistaya sistema, Binom-press, 2007, 855 pp.

[5] Cha C.Y., Himeno Y., Shimayoshi T., Amano A., Noma A., “A novel method to quantify contribution of channels and transporters to membrane potential dynamics”, Biophysical Journal, 97:12 (2009), 3086–3094 | DOI

[6] Solovyova O., Vikulova N., Markhasin V.S., Kohl P., “A novel method for quantifying the contribution of different intracellular mechanisms to mechanically induced changes in action potential characteristics”, Lecture Notes in Computer Science, 2674, 2003, 7–16 | DOI

[7] Garny A., Noble D., Hunter P.J. and Kohl P., “Cellular Open Resource (COR): current status and future directions”, Philosophical Transactions of the Royal Society, 367:1895 (2009), 1885–1905 ; URL: (дата обращения: 01.08.2011) http://cor.physiol.ox.ac.uk/ | DOI | MR