Сonnection of shape of globular proteins with their folding and unfolding rates

N. S. Bogatyreva ; D. N. Ivankov ; M. Yu. Lobanov ; O. V. Galzitskaya

Matematičeskaâ biologiâ i bioinformatika, Tome 3 (2008) no. 2, pp. 69-78.

Résumé

The problem of protein self-organization is one of the most important problems of molecular biology nowadays. Despite the recent success in understanding general principles of protein folding, details of this process is yet to be elucidated. That is why the search for the factors influencing protein folding kinetics is going on. We check in this study the hypothesis that more spherical proteins should fold more slowly than elongated ones. To this aim we analyze a number of structural determinants, designed for description protein shape, as well as their relationship with rates of protein folding and unfolding. We show here that dimensionless structural parameters describing protein shape have low correlation with protein folding and unfolding rates. At the same time structural determinants taking into account both protein shape and its size show good agreement with experimentally observed rates of protein folding and unfolding.

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