Geodesic
Magnetic particles as a carrier to select aptamer for survivin (BIRC5), a low molecular weight protein tumor marker
Žurnal Sibirskogo federalʹnogo universiteta. Matematika i fizika, Tome 17 (2024) no. 6, pp. 769-775.

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Magnetic iron oxide nanoparticles modified with aminosiloxane ($\gamma$-Fe$_2$O$_3$@SiO$_2$-NH$_2$) were used as a carrier to select DNA aptamers for a small protein tumor biomarker survivin (BIRC5, 16.5 kDa) from a randomized synthetic DNA library by the SELEX method. Survivin was covalently immobilized on the nanoparticles’ surface. The library enrichment was monitored by solid-phase bioluminescent immunoassay and the DNA melting method. The prospects are outlined for the use of the obtained nanoparticles for the effective selection of aptamers specific to a given target.
Keywords: DNA aptamers, survivin (BIRC5)
Mots-clés : magnetic nanoparticles. 
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     title = {Magnetic particles as a carrier to select aptamer for survivin {(BIRC5),} a low molecular weight protein tumor marker},
     journal = {\v{Z}urnal Sibirskogo federalʹnogo universiteta. Matematika i fizika},
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Nikita S. Panamarev; Anna V. Tyumentseva; Vasilisa V. Krasitskaya; Ludmila A. Frank. Magnetic particles as a carrier to select aptamer for survivin (BIRC5), a low molecular weight protein tumor marker. Žurnal Sibirskogo federalʹnogo universiteta. Matematika i fizika, Tome 17 (2024) no. 6, pp. 769-775. http://geodesic.mathdoc.fr/item/JSFU_2024_17_6_a8/

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