Geodesic
Magnetic particles as a carrier to select aptamer for survivin (BIRC5), a low molecular weight protein tumor marker
Žurnal Sibirskogo federalʹnogo universiteta. Matematika i fizika, Tome 17 (2024) no. 6, pp. 769-775

Voir la notice de l'article provenant de la source Math-Net.Ru

Magnetic iron oxide nanoparticles modified with aminosiloxane ($\gamma$-Fe$_2$O$_3$@SiO$_2$-NH$_2$) were used as a carrier to select DNA aptamers for a small protein tumor biomarker survivin (BIRC5, 16.5 kDa) from a randomized synthetic DNA library by the SELEX method. Survivin was covalently immobilized on the nanoparticles’ surface. The library enrichment was monitored by solid-phase bioluminescent immunoassay and the DNA melting method. The prospects are outlined for the use of the obtained nanoparticles for the effective selection of aptamers specific to a given target.
Keywords: DNA aptamers, survivin (BIRC5)
Mots-clés : magnetic nanoparticles. 
@article{JSFU_2024_17_6_a8,
     author = {Nikita S. Panamarev and Anna V. Tyumentseva and Vasilisa V. Krasitskaya and Ludmila A. Frank},
     title = {Magnetic particles as a carrier to select aptamer for survivin {(BIRC5),} a low molecular weight protein tumor marker},
     journal = {\v{Z}urnal Sibirskogo federalʹnogo universiteta. Matematika i fizika},
     pages = {769--775},
     publisher = {mathdoc},
     volume = {17},
     number = {6},
     year = {2024},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/JSFU_2024_17_6_a8/}
}
TY  - JOUR
AU  - Nikita S. Panamarev
AU  - Anna V. Tyumentseva
AU  - Vasilisa V. Krasitskaya
AU  - Ludmila A. Frank
TI  - Magnetic particles as a carrier to select aptamer for survivin (BIRC5), a low molecular weight protein tumor marker
JO  - Žurnal Sibirskogo federalʹnogo universiteta. Matematika i fizika
PY  - 2024
SP  - 769
EP  - 775
VL  - 17
IS  - 6
PB  - mathdoc
UR  - http://geodesic.mathdoc.fr/item/JSFU_2024_17_6_a8/
LA  - en
ID  - JSFU_2024_17_6_a8
ER  - 
%0 Journal Article
%A Nikita S. Panamarev
%A Anna V. Tyumentseva
%A Vasilisa V. Krasitskaya
%A Ludmila A. Frank
%T Magnetic particles as a carrier to select aptamer for survivin (BIRC5), a low molecular weight protein tumor marker
%J Žurnal Sibirskogo federalʹnogo universiteta. Matematika i fizika
%D 2024
%P 769-775
%V 17
%N 6
%I mathdoc
%U http://geodesic.mathdoc.fr/item/JSFU_2024_17_6_a8/
%G en
%F JSFU_2024_17_6_a8
Nikita S. Panamarev; Anna V. Tyumentseva; Vasilisa V. Krasitskaya; Ludmila A. Frank. Magnetic particles as a carrier to select aptamer for survivin (BIRC5), a low molecular weight protein tumor marker. Žurnal Sibirskogo federalʹnogo universiteta. Matematika i fizika, Tome 17 (2024) no. 6, pp. 769-775. http://geodesic.mathdoc.fr/item/JSFU_2024_17_6_a8/