A multi-scale epidemic model of Salmonella infection with heterogeneous shedding
ESAIM. Proceedings, Tome 67 (2020), pp. 261-284
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Salmonella strains colonize the digestive tract of farm livestock, such as chickens or pigs, without affecting them, and potentially infect food products, representing a threat for human health ranging from food poisoning to typhoid fever. It has been shown that the ability to excrete the pathogen in the environment and contaminate other animals is variable. This heterogeneity in pathogen carriage and shedding results from interactions between the host’s immune response, the pathogen and the commensal intestinal microbiota. In this paper we propose a novel generic multiscale modeling framework of heterogeneous pathogen transmission in an animal population. At the intra-host level, the model describes the interaction between the commensal microbiota, the pathogen and the inflammatory response. Random fluctuations in the ecological dynamics of the individual microbiota and transmission at between-host scale are added to obtain a drift-diffusion PDE model of the pathogen distribution at the population level. The model is further extended to represent transmission between several populations. The asymptotic behavior as well as the impact of control strategies including cleaning and antimicrobial administration are investigated through numerical simulation.
Affiliations des auteurs :
Simon Labarthe 1 ; Béatrice Laroche 1 ; Thi Nhu Thao Nguyen 2 ; Bastien Polizzi 3 ; Florian Patout 4 ; Magali Ribot 5 ; Tabea Stegmaier 6
@article{EP_2020_67_a15,
author = {Simon Labarthe and B\'eatrice Laroche and Thi Nhu Thao Nguyen and Bastien Polizzi and Florian Patout and Magali Ribot and Tabea Stegmaier},
title = {A multi-scale epidemic model of {Salmonella} infection with heterogeneous shedding},
journal = {ESAIM. Proceedings},
pages = {261--284},
year = {2020},
volume = {67},
doi = {10.1051/proc/202067015},
language = {en},
url = {http://geodesic.mathdoc.fr/articles/10.1051/proc/202067015/}
}
TY - JOUR AU - Simon Labarthe AU - Béatrice Laroche AU - Thi Nhu Thao Nguyen AU - Bastien Polizzi AU - Florian Patout AU - Magali Ribot AU - Tabea Stegmaier TI - A multi-scale epidemic model of Salmonella infection with heterogeneous shedding JO - ESAIM. Proceedings PY - 2020 SP - 261 EP - 284 VL - 67 UR - http://geodesic.mathdoc.fr/articles/10.1051/proc/202067015/ DO - 10.1051/proc/202067015 LA - en ID - EP_2020_67_a15 ER -
%0 Journal Article %A Simon Labarthe %A Béatrice Laroche %A Thi Nhu Thao Nguyen %A Bastien Polizzi %A Florian Patout %A Magali Ribot %A Tabea Stegmaier %T A multi-scale epidemic model of Salmonella infection with heterogeneous shedding %J ESAIM. Proceedings %D 2020 %P 261-284 %V 67 %U http://geodesic.mathdoc.fr/articles/10.1051/proc/202067015/ %R 10.1051/proc/202067015 %G en %F EP_2020_67_a15
Simon Labarthe; Béatrice Laroche; Thi Nhu Thao Nguyen; Bastien Polizzi; Florian Patout; Magali Ribot; Tabea Stegmaier. A multi-scale epidemic model of Salmonella infection with heterogeneous shedding. ESAIM. Proceedings, Tome 67 (2020), pp. 261-284. doi: 10.1051/proc/202067015
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