Geodesic
Improving Cancer Therapy by Doxorubicin and Granulocyte Colony-Stimulating Factor: Insights from a Computerized Model of Human Granulopoiesis
V. Vainstein1 ; Y. Ginosar1 ; M. Shoham2 ; A. Ianovski2 ; A. Rabinovich2 ; Y. Kogan1 ; V. Selitser1 ; Z. Agur1, 2
1 Institute for Medical Biomathematics (IMBM), POB 282 Hate'ena 10, Bene Ataroth, 60991 Israel
2 Optimata Ltd, 7 Abba Hillel Silver St., Ramat-Gan, 52522 Israel
Mathematical modelling of natural phenomena, Tome 1 (2006) no. 2, pp. 70-80.

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Neutropenia is a significant dose-limiting toxicity of cancer chemotherapy, especially in dose-intensified regimens. It is widely treated by injections of Granulocyte Colony-Stimulating Factor (G-CSF). However, optimal schedules of G-CSF administration are still not determined. In order to aid in identifying more efficacious and less neutropenic treatment protocols, we studied a detailed physiologically-based computer model of granulopoiesis, as affected by different treatment schedules of doxorubicin and/or Granulocyte Colony-Stimulating Factor (G-CSF). We validated the model as evident from accurate prediction of clinical data on human granulopoiesis in healthy individuals and in doxorubicin-treated cancer patients, with or without G-CSF support. Based on our model, we suggest new G-CSF administration regimens. These regimens include reduced G-CSF doses, optimally timed post-chemotherapy. Application of these regimens can lead to minimization of G-CSF side effects, as well as more cost-effective and less myelotoxic protocols. Currently clinical trials are being designed in order to test these new treatment regimens.
DOI : 10.1051/mmnp:2008003

V. Vainstein 1 ; Y. Ginosar 1 ; M. Shoham 2 ; A. Ianovski 2 ; A. Rabinovich 2 ; Y. Kogan 1 ; V. Selitser 1 ; Z. Agur 1, 2

1 Institute for Medical Biomathematics (IMBM), POB 282 Hate'ena 10, Bene Ataroth, 60991 Israel
2 Optimata Ltd, 7 Abba Hillel Silver St., Ramat-Gan, 52522 Israel 
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     author = {V. Vainstein and Y. Ginosar and M. Shoham and A. Ianovski and A. Rabinovich and Y. Kogan and V. Selitser and Z. Agur},
     title = {Improving {Cancer} {Therapy} by {Doxorubicin} and {Granulocyte} {Colony-Stimulating} {Factor:} {Insights} from a {Computerized} {Model} of {Human} {Granulopoiesis}},
     journal = {Mathematical modelling of natural phenomena},
     pages = {70--80},
     publisher = {mathdoc},
     volume = {1},
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     doi = {10.1051/mmnp:2008003},
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     url = {http://geodesic.mathdoc.fr/articles/10.1051/mmnp:2008003/}
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V. Vainstein; Y. Ginosar; M. Shoham; A. Ianovski; A. Rabinovich; Y. Kogan; V. Selitser; Z. Agur. Improving Cancer Therapy by Doxorubicin and Granulocyte Colony-Stimulating Factor: Insights from a Computerized Model of Human Granulopoiesis. Mathematical modelling of natural phenomena, Tome 1 (2006) no. 2, pp. 70-80. doi : 10.1051/mmnp:2008003. http://geodesic.mathdoc.fr/articles/10.1051/mmnp:2008003/

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