Optimal multiplicative control of bacterial quorum sensing under external enzyme impact

Anna Maslovskaya¹ ; Christina Kuttler² ; Alexander Chebotarev³ ; Andrey Kovtanyuk^4, 5

¹ Department of Mathematics and Computer Science, Amur State University, Ignatievskoe shosse 21, 675027 Blagoveshchensk, Russia
² Fakultät für Mathematik, Technische Universität München, Boltzmannstr. 3, 85747 Garching bei München, Germany
³ Institute for Applied Mathematics FEB RAS, Radio st. 7, 690041 Vladivostok, Russia
⁴ Klinikum rechts der Isar, Technische Universität München, Ismaningerstr. 22, 81675 München, Germany
⁵ Far Eastern Federal University, Far Eastern Center for Research and Education in Mathematics, Ajax Bay 10, Russky Island, 690922 Vladivostok, Russia

Mathematical modelling of natural phenomena, Tome 17 (2022), article no. 29

Résumé

The use of external enzymes provides an alternative way of reducing communication in pathogenic bacteria that may lead to the degradation of their signal and the loss of their pathogeneity. The present study considers an optimal control problem for the semilinear reaction-diffusion model of bacterial quorum sensing under the impact of external enzymes. Estimates of the solution of the controlled system are obtained, on the basis of which the solvability of the extremal problem is proved and the necessary optimality conditions of the first-order are derived. A numerical algorithm to find a solution of the optimal control problem is constructed and implemented. The conducted numerical experiments demonstrate an opportunity to build an effective strategy of the enzymes impact for treatment.

Détail

DOI : 10.1051/mmnp/2022031

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