A parametric stochastic model of bone geometry

V. I. Zalyapin ; Yu. S. Timofeev ; E. A. Shishkina

Vestnik Ûžno-Uralʹskogo gosudarstvennogo universiteta. Seriâ, Matematičeskoe modelirovanie i programmirovanie, Tome 11 (2018) no. 2, pp. 44-57

Résumé

The aim of the present study is to develop a parametric bone modelling algorithm which takes into account bone microarchitecture. This approach allows to generate hematopoietic bone segment phantoms based on literature-derived micro- and macro dimensions. We propose a method for subdividing bones into small segments which can be described by simple geometric shapes filled with a stochastically generated rod-like model of the trabecular structure with appropriate voxel resolution. This approach avoids the disadvantages of non-parametric individual modelling based on computer tomography scans. The parametric method allows the simulation of individual variability in bone-specific dimensions. The model presented in this paper will be used to describe the geometry of hematopoietic sites, which in turn will serve as a basis for calculating the doses of irradiation of the hematopoietic cells of the bone marrow from the incorporated beta-emitters.

Détail

Keywords: micro- and macro- structure of the trabecular bone; stochastic modelling; voxelization.

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