Geodesic
Peculiarities of Drosophila melanogaster adaptive reaction to a benzazolide genotoxicity of various molecular structure
Vestnik Samarskogo universiteta. Estestvennonaučnaâ seriâ, no. 4 (2010), pp. 200-207 Cet article a éte moissonné depuis la source Math-Net.Ru

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It was found out that benzimidazole and its derivatives authentically differ in their ability to induce dominant lethal mutations at Drosophila melanogaster both in semilethal, and in nontoxical doses as well. Drosophila fly males are more sensitive to a mutagen benzimidazole action, than females. Mutagenecity correlated negatively with values of the molecular weight and molecular volume, and positively – with value of the hydration energy. Short-term and long-term influence by a nontoxical dose of substances are analyzed, a preadaptation to the subsequent genotoxic action of substances in dose LD50 is created. A preadaptation possibility by a benzimidazole nontoxical dose to its derivatives genotoxicity have been revealed.
Mots-clés : dominant lethal mutations, adaptations.
Keywords: Drosophila melanogaster, benzimidazole derivatives 
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E. S. Selezneva; E. I. Ten'gaev. Peculiarities of Drosophila melanogaster adaptive reaction to a benzazolide genotoxicity of various molecular structure. Vestnik Samarskogo universiteta. Estestvennonaučnaâ seriâ, no. 4 (2010), pp. 200-207. http://geodesic.mathdoc.fr/item/VSGU_2010_4_a24/

[1] Belokon E. M., Metodicheskie ukazaniya k opredeleniyu mutatsionnoi aktivnosti khimicheskikh preparatov na drozofile, Izd-vo Lvovskogo gos. un-ta, Lvov, 1984, 26 pp.

[2] Zhukovskii A. G., Buga S. F., “Chuvstvitelnost populyatsii griba F. nivale, parazitiruyuschego na ozimoi tritikale k fundazolu”, Zaschita rastenii, sb. nauchn. tr., no. 27, Minsk, 2003, 84–89

[3] Kadyrov G. Sh., “Khimiya i pestitsidnaya aktivnost benzimidazolidov”, Regulyatory rosta rastenii i gerbitsidy, FAN, Tashkent, 1978, 65–123

[4] Lakin G. F., Biometriya, Vysshaya shkola, M., 1990, 352 pp.

[5] Lyubimova I. K., Abilev S. K., Migachev G. I., “Vliyanie nekotorykh strukturnykh osobennostei v molekulakh proizvodnykh pirena i ego geterotsiklicheskikh analogov na mutagennuyu aktivnost”, Genetika, 31:1 (1995), 128–132

[6] Lyubimova I. K., Abilev S. K., Migachev G. I., “Vzaimosvyaz mezhdu mutagennoi aktivnostyu i khimicheskoi strukturoi v ryadu proizvodnykh bifenila”, Genetika, 31:2 (1995), 268–272 | MR

[7] Mashkovskii M. D., Lekarstvennye sredstva, v 2 t., v. 2, Meditsina, M., 1993, 736 pp.

[8] Melnikov I. N., Pestitsidy, khimiya, tekhnologiya i primenenie, Khimiya, M., 1987, 721 pp.

[9] Ovchinnikov Yu. A., Bioorganicheskaya khimiya, Prosveschenie, M., 1987, 815 pp.

[10] Selezneva E. S., “Izmenenie tsitogeneticheskoi aktivnosti geterotsiklicheskikh azolov pri vvedenii v ikh stroenie metilnykh grupp”, Tatischevskie chteniya: aktualnye problemy nauki i praktiki. Ser.: Aktualnye problemy ekologii i okhrany okruzhayuschei sredy, materialy 5 yubileinoi mezhdunar. konf., Izd-vo “Tatischevskii universitet”, Tolyatti, 2008, 21–217

[11] I. E. Nifantev i dr., “Sintez i issledovanie mutagennoi aktivnosti di(indeno/2,1-b/indolil)-, di(indeno/2,1-b/pirolil)metanov i dimetilsilanov”, Izvestiya RAN. Ser.: Khimicheskaya, 2001, no. 5, 1369–1375

[12] A. A. Spasov i dr., “Spektr farmakologicheskoi aktivnosti i toksikologicheskie svoistva proizvodnykh benzimidazola”, Khimiko-farmatsevticheskii zhurn., 1999, no. 5, 6–17

[13] A. K. Lees et al., “Analysis of variation within Microdochium nivale from wheat: evidence for a distinct sub-group”, Mycol. Res., 99 (1995), 103–109 | DOI

[14] P. Ernsberger et al., “I1-imidazoline receptors. Definition, characterisation, distribution and transmembrane signalling”, Ann. N.Y. Acad. Sci., 763 (1995), 22–42 | DOI