Geodesic
Interaction of $\mathrm{TOEPyP4}$ porphyrin with $\mathrm{A}$ form of DNA
Proceedings of the Yerevan State University. Physical and mathematical sciences, no. 3 (2014), pp. 43-48

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The peculiarities of binding the water-soluble meso-tetra-(4N-oxyethylpyridyl) porphyrin ($\mathrm{TOEPyP4}$) with $\mathrm{B}$-DNA and $\mathrm{A}$-DNA have been studied by means of UV-VIS spectrophotometry and circular dichroism method. The binding constant ($K_b$) and stoichiometry ($n$) were determined based on the absorbance spectra for each DNA–porphyrin complex. The free energy, enthalpy and entropy of binding also were calculated using the values of $K_b$. A comparative analysis with $\mathrm{TOEPyP4-B}$-DNA complex was performed. The obtained results show that the porphyrin interacts with $\mathrm{B}$-DNA by way of intercalation at low relative concentrations ($r = C_{porf}/C_{DNA}$) and external binding at large values of $r$, whereas the interaction of $\mathrm{TOEPyP4}$ with $\mathrm{A}$-DNA occurs via the outside binding mode only.
Keywords: porphyrin, thermodynamics, absorbance spectra, circular dichroism.
Mots-clés : DNA conformation 
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     author = {A. A. Avetisyan},
     title = {Interaction of $\mathrm{TOEPyP4}$  porphyrin with $\mathrm{A}$  form of {DNA}},
     journal = {Proceedings of the Yerevan State University. Physical and mathematical sciences},
     pages = {43--48},
     publisher = {mathdoc},
     number = {3},
     year = {2014},
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A. A. Avetisyan. Interaction of $\mathrm{TOEPyP4}$  porphyrin with $\mathrm{A}$  form of DNA. Proceedings of the Yerevan State University. Physical and mathematical sciences, no. 3 (2014), pp. 43-48. http://geodesic.mathdoc.fr/item/UZERU_2014_3_a7/