Influenza della morfina e dell'eroina sui processi di consolidazione della memoria del topo

Castellano, Claudio ; Gasbarra, Rita

Atti della Accademia nazionale dei Lincei. Rendiconti della Classe di scienze fisiche, matematiche e naturali, Série 8, Tome 56 (1974) no. 6, pp. 996-1003.

Résumé

Morphine and heroin have been injected in DBA/2J mice during a light-dark discrimination learning, in the Y water maze. From the analysis of the performances inside each session and between two consecutive sessions, an impairment in the long term memory consolidation processes of the opiates injected animals has been evident, as compared to saline injected controls. The results are discussed on the basis of the dualistic concept of memory, and of recent neurophysiological acquisitions on the REM phase of sleep, and its relationship with opiate administration.

Bibliographie

Banerjee U. (1971) - Acquisition of conditioned avoidance response in rats under the influence of addicting drugs, «Psychopharmacologia (Berl.)», 22, 133-143.

Bovet D., Bovet-Nitti F. e Oliverio A. (1969) - Genetic aspects of learning and memory in mice, «Science», 163, 139-140.

Castellano C. (1971) - Lysergic acid diethylamide, amphetamine and chlorpromazine on water maze discrimination in mice, «Psychopharmacologia (Berl.)», 19, 16-25.

Castellano C. (1971) - Effects of some anticholinergic drugs on water maze learned behaviour in mice, «Psychopharmacologia (Berl.)», 21, 361-369.

Castellano C. (1973) - Morphine, mescaline, cocaine on water maze discrimination in mice, «Psychopharmacologia (Berl.)», 28, 147-153.

Castellano C. (1974) - Cocaine Pemoline and Amphetamine on learning and retention of a discrimination test in mice, «Psychopharmacologia (Berl.)», 36, 67-76.

Clark K. e Samuel G. K. (1969) - Drug effects in a discrete conditioned avoidance response in dogs, rhesus monkeys and rats, «Psychopharmacologia (Berl.)», 14, 148-155.

Cook L. and Weidley E. F. (1957) - Behavioral effects of some psychopharmacological agents, «Ann. N. Y. Acad. Sci.», 66, 740-753.

Echols S. D. e Jewett R. E. (1972) - Effects of morphine on sleep in the cat, «Psychopharmaqologia (Berl.)», 24, 435-448.

Feldman R. E. (1969) - The effect of deprivation of rapid eye movement sleep on learning and retention in humans. Ph. D. Thesis, Standord University.

Fishbein W. (1969) - The effects of paradoxical sleep deprivation, «Psychophysiology», 6, 225-226.

Fishbein W. (1975) - Retrograde amnesia: Electroconvulsive shock effects after termination of rapid eye movement sleep deprivation, «Science», 172, 80-82.

Hill H. E., Pescor F. T., Belleville R. E. e Wikler A. (1957) - Use of differential barpressing rate of rats for screening analgesic drugs: techniques and effects of morphine, «J. Pharmac. Exp. Ther.», 120, 388-397.

Holten C. H. e Sonne E. (1955) - Action of a series of benactyzine derivatives and other compounds on stress induced behaviour in the rat, «Acta pharmac. (Kbh.)», II, 148-155.

Jarvik M. E. (1964) - The influence of drugs upon memory, in Steinberg H. (Ed.) Animal Behaviour and drug action, London, Churchill.

Jouvet M. (1967) - Mechanisms of states of sleep. A neuropharmacological approach. Research Publications of the Association for the Research in «Nervous and Mental Disease», 45, 86-126.

Kay D. C., Eisenstein R. B. e Jasinski D. R. (1969) - Morphine effects on human REM state, waking state, and NREM sleep, «Psychopharmacologia (Berl.)», 14, 404-416.

Khazan D. C., Weeks J. R. e Schroder L. A. (1967) - Electroencephalographic, electromyografic and behavioral correlates during a cycle of self-maintaining morphine addiction in the rat, «J. Pharmac. Exp. Ther.», 155, 521-531.

Le Conte P. e Bloch V. (1970) - Deficit de la retention d'un conditionnement après privation de sommeil paradoxal chez le rat, «C. R. Acad. Sc. Paris», 5, 271.

Lucero M. (1970) - Lengthening of REM sleep duration consecutive learning in the rat, «Brain Res.», 20, 319-322.

Mcgaugh J. L. e Petrinovich L. F. (1965) - Effects of drugs on learning and memory, «Intern. Rev. Neurobiol.», 8, 139-196.

Maynert E. W. e Levi R. (1964) - Stress-induced release of brain norepinephrine and its inhibition by drugs, «J. Pharmac. Exp. Ther.», 143, 90-95.

Pagel J., Pegram V., Vaughn S., Donaldson P. and Bridgers W. (1973) - The relationship of REM sleep with learning and memory in mice, «Behavioral Biology», 9, 383-388.

Pearlman C. A. e Greenburg R. (1972) - Brief REM deprivation impairs consolidation of complex learning in rats, «Psychophysiology», 9, 109-110.

Pearlman C. A. (1969) - Effect of rapid eye movement (dreaming) sleep deprivation on retention of avoidance learning in rats, «Psychon. Sic.», 25 (3), 135-136.

Sansone M., Olivierio A., Renzi P. e Bovet D. (1969) - Water maze discrimination learning in mice. Communications in «Behavioral Biology», 4, 115-119.

Stern W. C. (1970) - The relationship between REM sleep and learning: animal studies of the D-state, dreaming and memory, «Sleep Dreaming Int. Psychiat. Clinics», 7, 249-257.