Geodesic
Natural polyphenols as potential antibacterial agents and their delivery systems of nanosized level
Nanosistemy: fizika, himiâ, matematika, Tome 15 (2024) no. 6, pp. 936-949 Cet article a éte moissonné depuis la source Math-Net.Ru

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Bacterial infections associated with multidrug-resistant pathogens are a serious danger to both humans and farm animals. For this reason, natural biologically active agents (BAA), in particular, polyphenols, with a wide range of biological activity could become promising molecules for effective antibacterial therapy. Despite the potentially high antibacterial activity and other beneficial biological effects, the use of such BAA is hindered due to their low water solubility. To overcome this problem, various approaches are used, for example, loading BAA into nanosized delivery systems (nanoparticles, nanocapsules, micelles, etc.). Such approaches allow not only to increase the effectiveness of natural BAA, but also to ensure their targeted (local) effect, which is important in the treatment of bacterial diseases, and in some cases result in synergic action. This review describes the antibacterial properties of the most promising polyphenols and key approaches for their delivery at the nanoscale level, as well as the methods for their development.
Keywords: polyphenolic agents, antibacterial activity, natural biologically active agents, carnosic acid, curcumin, mangiferin, rosmarinic acid, drug resistance, analysis methods.
Mots-clés : nanoparticles 
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     author = {Vladislava I. Klimshina and Roman O. Shaikenov and Svetlana N. Morozkina and Aleksey E. Romanov and Petr P. Snetkov},
     title = {Natural polyphenols as potential antibacterial agents and their delivery systems of nanosized level},
     journal = {Nanosistemy: fizika, himi\^a, matematika},
     pages = {936--949},
     year = {2024},
     volume = {15},
     number = {6},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/NANO_2024_15_6_a19/}
}
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Vladislava I. Klimshina; Roman O. Shaikenov; Svetlana N. Morozkina; Aleksey E. Romanov; Petr P. Snetkov. Natural polyphenols as potential antibacterial agents and their delivery systems of nanosized level. Nanosistemy: fizika, himiâ, matematika, Tome 15 (2024) no. 6, pp. 936-949. http://geodesic.mathdoc.fr/item/NANO_2024_15_6_a19/