Geodesic
Physicochemical properties and biological activity of novel cerium oxide nanoparticles modified with pyrroloquinoline quinone
Nanosistemy: fizika, himiâ, matematika, Tome 15 (2024) no. 5, pp. 683-692.

Voir la notice de l'article provenant de la source Math-Net.Ru

Nanoscale cerium oxide (CeO$_2$) is a bioavailable inorganic nanozyme exhibiting pronounced redox activity and capable of acting as a delivery system for bioactive compounds. We have synthesized and characterized novel CeO$_2$ nanoparticles modified with pyrroloquinoline quinone (CeO$_2$@PQQ). TEM analysis revealed the diameter of the CeO$_2$@PQQ NPs to be approximately 4 nm, with a hydrodynamic diameter of 62 nm (DLS). Furthermore, the zeta potential was found to be -38 mV (ELS), and FTIR analysis confirmed the adsorption of PQQ on the surface of CeO$_2$ NPs. The results demonstrated that CeO$_2$@PQQ NPs exhibited no cytotoxic effects on L929 cells within the concentration range of 0.1 – 10 $\mu$M and did not adversely affect the mitochondrial function of the cells. It was demonstrated that CeO$_2$@PQQ NPs exhibited protective effects against L929 cells when induced with oxidative stress (200 $\mu$M H$_2$O$_2$), leading to preservation of cell mitochondrial potential levels up to 76% of control and cell viability up to 78% before and after incubation with CeO$_2$@PQQ NPs. The results indicate that CeO$_2$@PQQ NPs can be regarded as a novel hybrid nanosystem that exhibits mitochondrial-directed control of oxidative stress.
Keywords: oxidative stress, reactive oxygen species, antioxidants, nanocrystalline cerium oxide, CeO$_2$, pyrroloquinoline quinone, PQQ, mitochondria.
Mots-clés : nanoparticles 
@article{NANO_2024_15_5_a11,
     author = {Elizaveta A. Zamyatina and Olga A. Goryacheva and Nelli R. Popova},
     title = {Physicochemical properties and biological activity of novel cerium oxide nanoparticles modified with pyrroloquinoline quinone},
     journal = {Nanosistemy: fizika, himi\^a, matematika},
     pages = {683--692},
     publisher = {mathdoc},
     volume = {15},
     number = {5},
     year = {2024},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/NANO_2024_15_5_a11/}
}
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Elizaveta A. Zamyatina; Olga A. Goryacheva; Nelli R. Popova. Physicochemical properties and biological activity of novel cerium oxide nanoparticles modified with pyrroloquinoline quinone. Nanosistemy: fizika, himiâ, matematika, Tome 15 (2024) no. 5, pp. 683-692. http://geodesic.mathdoc.fr/item/NANO_2024_15_5_a11/