Geodesic
Cellular uptake of FITC-labeled Ce$_{0.8}$Gd$_{0.2}$O$_{2-x}$ nanoparticles in 2D and 3D mesenchymal stem cell systems
Nanosistemy: fizika, himiâ, matematika, Tome 15 (2024) no. 3, pp. 352-360.

Voir la notice de l'article provenant de la source Math-Net.Ru

Cerium-containing nanoparticles have recently been identified as promising nanozymes for advanced biomedical applications. Additional modification of the core or the surface of CeO$_2$ nanoparticles (CeO$_2$ NPs) provides them with new functionalities, making them a unique theranostic agent. In this study, dextran-stabilized CeO$_2$ NPs doped with Gd (Ce$_{0.8}$Gd$_{0.2}$O$_{2-x}$) were synthesized and further functionalized with fluorescein isothiocyanate (FITC). The synthesized nanoparticles have a high degree of biocompatibility at concentrations up to 5 mg/mL and are readily internalized by human mesenchymal stem cells cultured both in monolayers (2D system) and cellular spheroids (3D system). The functionalization of CeO$_2$ NPs with Gd and FITC dye allows for monitoring their accumulation within organs and tissues using both magnetic resonance imaging (MRI) and fluorescence spectroscopy techniques.
Keywords: 3D cell spheroid, cerium, gadolinium.
Mots-clés : nanoparticles 
@article{NANO_2024_15_3_a5,
     author = {Danil D. Kolmanovich and Nikita N. Chukavin and N. A. Pivovarov and Sergey A. Khaustov and Vladimir K. Ivanov and Anton L. Popov},
     title = {Cellular uptake of {FITC-labeled} {Ce}$_{0.8}${Gd}$_{0.2}${O}$_{2-x}$ nanoparticles in {2D} and {3D} mesenchymal stem cell systems},
     journal = {Nanosistemy: fizika, himi\^a, matematika},
     pages = {352--360},
     publisher = {mathdoc},
     volume = {15},
     number = {3},
     year = {2024},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/NANO_2024_15_3_a5/}
}
TY  - JOUR
AU  - Danil D. Kolmanovich
AU  - Nikita N. Chukavin
AU  - N. A. Pivovarov
AU  - Sergey A. Khaustov
AU  - Vladimir K. Ivanov
AU  - Anton L. Popov
TI  - Cellular uptake of FITC-labeled Ce$_{0.8}$Gd$_{0.2}$O$_{2-x}$ nanoparticles in 2D and 3D mesenchymal stem cell systems
JO  - Nanosistemy: fizika, himiâ, matematika
PY  - 2024
SP  - 352
EP  - 360
VL  - 15
IS  - 3
PB  - mathdoc
UR  - http://geodesic.mathdoc.fr/item/NANO_2024_15_3_a5/
LA  - en
ID  - NANO_2024_15_3_a5
ER  - 
%0 Journal Article
%A Danil D. Kolmanovich
%A Nikita N. Chukavin
%A N. A. Pivovarov
%A Sergey A. Khaustov
%A Vladimir K. Ivanov
%A Anton L. Popov
%T Cellular uptake of FITC-labeled Ce$_{0.8}$Gd$_{0.2}$O$_{2-x}$ nanoparticles in 2D and 3D mesenchymal stem cell systems
%J Nanosistemy: fizika, himiâ, matematika
%D 2024
%P 352-360
%V 15
%N 3
%I mathdoc
%U http://geodesic.mathdoc.fr/item/NANO_2024_15_3_a5/
%G en
%F NANO_2024_15_3_a5
Danil D. Kolmanovich; Nikita N. Chukavin; N. A. Pivovarov; Sergey A. Khaustov; Vladimir K. Ivanov; Anton L. Popov. Cellular uptake of FITC-labeled Ce$_{0.8}$Gd$_{0.2}$O$_{2-x}$ nanoparticles in 2D and 3D mesenchymal stem cell systems. Nanosistemy: fizika, himiâ, matematika, Tome 15 (2024) no. 3, pp. 352-360. http://geodesic.mathdoc.fr/item/NANO_2024_15_3_a5/