Geodesic
Cerium dioxide nanoparticles modulate the oxidative metabolism of neutrophils upon blood irradiation with a pulsed broadband UV source
Nanosistemy: fizika, himiâ, matematika, Tome 14 (2023) no. 6, pp. 644-651.

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The effect of CeO$_2$ nanoparticles on the oxidative activity of neutrophils under UV irradiation with a pulsed broadband UV source (210 mJ/cm$^2$) was analyzed. The effects of citrate-stabilized CeO$_2$ sol on spontaneous and stimulated by phorbol-12-myristate-13-acetate (PMA) and N-formylmethionyl-leucyl-phenylalanine (fMLP) luminol-dependent chemiluminescence of neutrophils were evaluated. The activating effect of CeO$_2$ nanoparticles on the spontaneous and suppressive effect on the stimulated chemiluminescence of blood neutrophils from apparently healthy donors was shown, with the most pronounced activating effect of CeO$_2$ nanoparticles revealed in the blood sample with initially high radical-producing cell activity. Under UV irradiation of blood at a dose of 210 mJ/cm$^2$ CeO$_2$ nanoparticles enhance both spontaneous and stimulated radical-producing function of neutrophils. Probably, the suppressive and activating effects of citrate-stabilised cerium dioxide sol may be due to the antioxidant activity of CeO$_2$ nanoparticles with respect to hypochlorite ions and prooxidant activity with respect to hydrogen peroxide.
Keywords: cerium dioxide nanoparticles, pulsed xenon UV lamp
Mots-clés : nanozymes, neutrophils, UV radiation, chemiluminescence. 
@article{NANO_2023_14_6_a3,
     author = {Madina M. Sozarukova and Polina A. Chilikina and Dmitry O. Novikov and Elena V. Proskurnina and Alexander Y. Baranchikov and Vladimir K. Ivanov},
     title = {Cerium dioxide nanoparticles modulate the oxidative metabolism of neutrophils upon blood irradiation with a pulsed broadband {UV} source},
     journal = {Nanosistemy: fizika, himi\^a, matematika},
     pages = {644--651},
     publisher = {mathdoc},
     volume = {14},
     number = {6},
     year = {2023},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/NANO_2023_14_6_a3/}
}
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%A Polina A. Chilikina
%A Dmitry O. Novikov
%A Elena V. Proskurnina
%A Alexander Y. Baranchikov
%A Vladimir K. Ivanov
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Madina M. Sozarukova; Polina A. Chilikina; Dmitry O. Novikov; Elena V. Proskurnina; Alexander Y. Baranchikov; Vladimir K. Ivanov. Cerium dioxide nanoparticles modulate the oxidative metabolism of neutrophils upon blood irradiation with a pulsed broadband UV source. Nanosistemy: fizika, himiâ, matematika, Tome 14 (2023) no. 6, pp. 644-651. http://geodesic.mathdoc.fr/item/NANO_2023_14_6_a3/