Geodesic
Cerium oxide@silica core-shell nanocomposite as multimodal platforms for drug release and synergistic anticancer effects
Nanosistemy: fizika, himiâ, matematika, Tome 14 (2023) no. 5, pp. 560-570.

Voir la notice de l'article provenant de la source Math-Net.Ru

Cerium oxide nanoparticles (CeNPs) are among the most promising materials with pH-sensitive redox-activity for biomedical nanotechnologies. CeNPs are known to reduce the toxicity of the chemotherapeutic drug doxorubicin (DOX) for normal cells. Here we have proposed and analyzed a new hybrid cerium/silica containing SiNPs@DOX@CeNPs nanocomposite. We showed that the average size of the nanocomposite is 190 nm and it has a spherical shape. The SiNPs@DOX@CeNPs nanocomposite provides effective synergistic anticancer activity of CeNPs with doxorubicin (DOX), as well as selective toxicity against human osteosarcoma (MNNG/HOS) cells in vitro. The SiNPs@DOX@CeNPs nanocomposite may be a good candidate to increase the effectiveness of cancer doxorubicin chemotherapy.
Keywords: cerium oxide nanoparticles, biomedical application, characterization, drug delivery.
Mots-clés : nanocomposites, silica nanoparticles 
@article{NANO_2023_14_5_a8,
     author = {Elizaveta A. Zamyatina and Sergey Yu. Kottsov and Viktoriia A. Anikina and Anton L. Popov and Marina P. Shevelyova and Nelli R. Popova},
     title = {Cerium oxide@silica core-shell nanocomposite as multimodal platforms for drug release and synergistic anticancer effects},
     journal = {Nanosistemy: fizika, himi\^a, matematika},
     pages = {560--570},
     publisher = {mathdoc},
     volume = {14},
     number = {5},
     year = {2023},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/NANO_2023_14_5_a8/}
}
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AU  - Sergey Yu. Kottsov
AU  - Viktoriia A. Anikina
AU  - Anton L. Popov
AU  - Marina P. Shevelyova
AU  - Nelli R. Popova
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%0 Journal Article
%A Elizaveta A. Zamyatina
%A Sergey Yu. Kottsov
%A Viktoriia A. Anikina
%A Anton L. Popov
%A Marina P. Shevelyova
%A Nelli R. Popova
%T Cerium oxide@silica core-shell nanocomposite as multimodal platforms for drug release and synergistic anticancer effects
%J Nanosistemy: fizika, himiâ, matematika
%D 2023
%P 560-570
%V 14
%N 5
%I mathdoc
%U http://geodesic.mathdoc.fr/item/NANO_2023_14_5_a8/
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Elizaveta A. Zamyatina; Sergey Yu. Kottsov; Viktoriia A. Anikina; Anton L. Popov; Marina P. Shevelyova; Nelli R. Popova. Cerium oxide@silica core-shell nanocomposite as multimodal platforms for drug release and synergistic anticancer effects. Nanosistemy: fizika, himiâ, matematika, Tome 14 (2023) no. 5, pp. 560-570. http://geodesic.mathdoc.fr/item/NANO_2023_14_5_a8/