Geodesic
Conjugation of curcumin with Ag nanoparticle for improving its bioavailability and study of the bioimaging response
Nanosistemy: fizika, himiâ, matematika, Tome 12 (2021) no. 4, pp. 528-535

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We report here the production of curcumin conjugated polyvinylpyrrolidone (PVP)-capped Ag nanoparticles for potential biological applications. Evidence for the efficient conjugation of hydrophobic curcumin to the synthesized nanoparticles (NPs) is expected from UV-Vis, zeta potential and Fourier transform infrared (FT-IR) analysis. Curcumin conjugated to PVP-capped Ag NPs is observed to gain high water solubility and bioavailability in a biological environment without diminishing its therapeutic properties. The presence of the main therapeutic group, the diarylheptanoid chromophore of curcumin, indicates the existence of its medicinal behavior in the curcumin-Ag NPs complex. Moreover, the fluorescence efficiency of PVP capped Ag NPs in the breast cancer cellular medium have been found to be significantly enhanced (by factor of $\sim$ 2.37) with curcumin conjugation. The production of bioavailable curcumin provides an opportunity to expand the clinical repertoire of this efficacious agent without hampering the environment and human health.
Keywords: therapeutic, bioavailability, imaging, curcumin, PVP. 
@article{NANO_2021_12_4_a14,
     author = {Runjun Sarma and Monoj Kumar Das and Lakshi Saikia and Anand Ramteke and Ratul Saikia},
     title = {Conjugation of curcumin with {Ag} nanoparticle for improving its bioavailability and study of the bioimaging response},
     journal = {Nanosistemy: fizika, himi\^a, matematika},
     pages = {528--535},
     publisher = {mathdoc},
     volume = {12},
     number = {4},
     year = {2021},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/NANO_2021_12_4_a14/}
}
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Runjun Sarma; Monoj Kumar Das; Lakshi Saikia; Anand Ramteke; Ratul Saikia. Conjugation of curcumin with Ag nanoparticle for improving its bioavailability and study of the bioimaging response. Nanosistemy: fizika, himiâ, matematika, Tome 12 (2021) no. 4, pp. 528-535. http://geodesic.mathdoc.fr/item/NANO_2021_12_4_a14/