Geodesic
Comprehensive cytotoxicity analysis of polysaccharide hydrogel modified with cerium oxide nanoparticles for wound healing application
Nanosistemy: fizika, himiâ, matematika, Tome 12 (2021) no. 3, pp. 329-335.

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This paper is aimed at the experimental study (in animal models) of acute toxicity and irritating properties of polysaccharide hydrogel modified with cerium oxide nanoparticles. In the acute experiment, there were no indications of irritating action of the gel at the site of application when the hydrogel was administered intragastrically or epicutaneously. No lethal effects were registered during this experiment even at the highest concentration. The results obtained demonstrate the lack of acute toxicity and local irritability of the synthesized hybrid hydrogel, which allows to classify the developed hybrid hydrogel as the relatively low-risk drug.
Keywords: wound healing, hydrogel, cerium oxide nanoparticles, epicutaneous application, regeneration, cell proliferation. 
@article{NANO_2021_12_3_a8,
     author = {A. L. Popov and V. V. Andreeva and N. V. Khohlov and K. A. Kamenskikh and V. B. Gavrilyuk and V. K. Ivanov},
     title = {Comprehensive cytotoxicity analysis of polysaccharide hydrogel modified with cerium oxide nanoparticles for wound healing application},
     journal = {Nanosistemy: fizika, himi\^a, matematika},
     pages = {329--335},
     publisher = {mathdoc},
     volume = {12},
     number = {3},
     year = {2021},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/NANO_2021_12_3_a8/}
}
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A. L. Popov; V. V. Andreeva; N. V. Khohlov; K. A. Kamenskikh; V. B. Gavrilyuk; V. K. Ivanov. Comprehensive cytotoxicity analysis of polysaccharide hydrogel modified with cerium oxide nanoparticles for wound healing application. Nanosistemy: fizika, himiâ, matematika, Tome 12 (2021) no. 3, pp. 329-335. http://geodesic.mathdoc.fr/item/NANO_2021_12_3_a8/