Geodesic
CeO$_{2}$ nanoparticles as free radical regulators in biological systems
Nanosistemy: fizika, himiâ, matematika, Tome 11 (2020) no. 3, pp. 324-332.

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Cerium dioxide nanoparticles possess unique physical and chemical properties, among which the enzyme-like activity is of particular interest. In particular, they are able to perform the functions of pro- and antioxidant enzymes, such as superoxide dismutase (SOD), catalase, and peroxidase. Due to the advantages associated with pH and temperature stability and low cost, CeO$_{2}$ nanoparticles can be considered as promising mimetics of these enzymes. In this paper, the antioxidant activity of a citrate-stabilized colloidal suspension of CeO$_{2}$ nanoparticles has been studied using chemiluminometry in model systems generating superoxide anion radical and hydrogen peroxide. In the lucigenin/xanthine/xanthine oxidase system, generating a superoxide anion radical, CeO$_{2}$ nanoparticles exhibit antioxidant properties increasing upon conjugation with SOD. When interacting with hydrogen peroxide, CeO$_{2}$ nanoparticles exhibit peroxidase-like activity. In the combined ROS generating system, lucigenin/Co(II)/H$_{2}$O$_{2}$, CeO$_{2}$ nanoparticles demonstrated prooxidant activity.
Keywords: cerium dioxide nanoparticles, superoxide anion radical, hydrogen peroxide, superoxide dismutase, peroxidase
Mots-clés : nanozymes, chemiluminescence. 
@article{NANO_2020_11_3_a8,
     author = {M. M. Sozarukova and E. V. Proskurnina and A. Y. Baranchikov and V. K. Ivanov},
     title = {CeO$_{2}$ nanoparticles as free radical regulators in biological systems},
     journal = {Nanosistemy: fizika, himi\^a, matematika},
     pages = {324--332},
     publisher = {mathdoc},
     volume = {11},
     number = {3},
     year = {2020},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/NANO_2020_11_3_a8/}
}
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M. M. Sozarukova; E. V. Proskurnina; A. Y. Baranchikov; V. K. Ivanov. CeO$_{2}$ nanoparticles as free radical regulators in biological systems. Nanosistemy: fizika, himiâ, matematika, Tome 11 (2020) no. 3, pp. 324-332. http://geodesic.mathdoc.fr/item/NANO_2020_11_3_a8/