Geodesic
Cerium oxide nanoparticles provide radioprotective effects upon X-ray irradiation by modulation of gene expression
Nanosistemy: fizika, himiâ, matematika, Tome 10 (2019) no. 5, pp. 564-572

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Nanocrystalline cerium dioxide is known as a unique redox active nanomaterial. Cerium dioxide is considered as the basis for future biomedical preparations, including radioprotectors. In the framework of this study, we synthesized citrate-stabilized CeO$_{2}$ nanoparticles and carried out a comprehensive in vitro assessment of their radioprotective properties on a NCTC L929 murine fibroblast culture. It was shown that CeO$_{2}$ nanoparticles ensure the survival of murine fibroblasts, even after high-dose X-ray irradiation, reducing the number of dead cells in the culture and modulating the mRNA level of the key antioxidant enzymes — superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2). The results obtained confirm the potential for studying the properties of CeO$_{2}$ nanoparticles as basic materials for designing new efficient and safe preparations for protection against ionizing radiation.
Keywords: cerium oxide nanoparticles, cytotoxicity, X-ray, ionizing radiation, fibroblasts.
Mots-clés : radioprotection 
@article{NANO_2019_10_5_a7,
     author = {N. R. Popova and T. O. Shekunova and A. L. Popov and I. I. Selezneva and V. K. Ivanov},
     title = {Cerium oxide nanoparticles provide radioprotective effects upon {X-ray} irradiation by modulation of gene expression},
     journal = {Nanosistemy: fizika, himi\^a, matematika},
     pages = {564--572},
     publisher = {mathdoc},
     volume = {10},
     number = {5},
     year = {2019},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/NANO_2019_10_5_a7/}
}
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N. R. Popova; T. O. Shekunova; A. L. Popov; I. I. Selezneva; V. K. Ivanov. Cerium oxide nanoparticles provide radioprotective effects upon X-ray irradiation by modulation of gene expression. Nanosistemy: fizika, himiâ, matematika, Tome 10 (2019) no. 5, pp. 564-572. http://geodesic.mathdoc.fr/item/NANO_2019_10_5_a7/