Geodesic
Humic acid-stabilized superparamagnetic maghemite nanoparticles: surface charge and embryotoxicity evaluation
Nanosistemy: fizika, himiâ, matematika, Tome 10 (2019) no. 2, pp. 184-189.

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Superparamagnetic iron oxide $\gamma$-Fe$_{2}$O$_{3}$ (maghemite) nanoparticles (SPION) encapsulated into water-soluble microspheres of rock salt were synthesized via a new aerosol spray pyrolysis procedure. Humic acids (HA) were employed to stabilize the aqueous suspensions of $\gamma$-Fe$_{2}$O$_{3}$ nanoparticles released upon dissolution of the NaCl matrix. The effect of HA on the surface charge of maghemite-based colloids was studied in pH range of 3–10. Humic polyanions compensate positive charges on a hydrated $\gamma$-Fe$_{2}$O$_{3}$ surface resulting in strongly negative $\zeta$-potential ($$ -40 mV) of colloid even in acidic environment. In neutral and alkaline environment, $\zeta$-potential of maghemite-based colloid drops below -55 mV; thus, HA should effectively stabilize the nanoparticle colloid over the whole pH range studied. Meanwhile, bare maghemite SPION at pH 3–6 have $\zeta$-potential in the +20 mV to -20 mV range (isoelectric point at pH 4.35), which is insufficient for electrostatic stabilization of the suspensions. The absence of embryotoxicity of HA-stabilized nanoparticles was demonstrated.
Keywords: small superparamagnetic iron oxide nanoparticles (SPION), humic acids, magnetic fluids, colloidal properties, embryotoxicity, biomedicine. 
@article{NANO_2019_10_2_a9,
     author = {A. E. Goldt and A. Yu. Polyakov and T. A. Sorkina and A. L. Dubov and G. A. Davidova and I. I. Selezneva and Yu. V. Maximov and I. A. Presnyakov and N. Yu. Polyakova and E. A. Goodilin and I. V. Perminova},
     title = {Humic acid-stabilized superparamagnetic maghemite nanoparticles: surface charge and embryotoxicity evaluation},
     journal = {Nanosistemy: fizika, himi\^a, matematika},
     pages = {184--189},
     publisher = {mathdoc},
     volume = {10},
     number = {2},
     year = {2019},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/NANO_2019_10_2_a9/}
}
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%A G. A. Davidova
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%A I. V. Perminova
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A. E. Goldt; A. Yu. Polyakov; T. A. Sorkina; A. L. Dubov; G. A. Davidova; I. I. Selezneva; Yu. V. Maximov; I. A. Presnyakov; N. Yu. Polyakova; E. A. Goodilin; I. V. Perminova. Humic acid-stabilized superparamagnetic maghemite nanoparticles: surface charge and embryotoxicity evaluation. Nanosistemy: fizika, himiâ, matematika, Tome 10 (2019) no. 2, pp. 184-189. http://geodesic.mathdoc.fr/item/NANO_2019_10_2_a9/