Geodesic
Cerium oxide nanoparticles increase the cytotoxicity of TNF-alpha in vitro
Nanosistemy: fizika, himiâ, matematika, Tome 9 (2018) no. 4, pp. 537-543

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Cerium oxide nanoparticles (CeONP) were used as the modifying agent for the recombinant tumor necrosis factor-$\alpha$ and recombinant tumor necrosis factor-$\alpha$-thymosin-$\alpha$1 (rhTNF and rhTNF-T). A notable increase of the biological activity of proteins with antitumor effect was demonstrated. It was established that the cytotoxicity of rTNF-T+CeONP composite increases with the duration of exposure to 7 days. Modification of rTNF-T with cerium oxide nanoparticles provides a stronger and more stable cytotoxic effect in Hep-2, L929, and A-549 tumor cell lines.
Keywords: cerium oxide nanoparticles, tumor necrosis factor, biological activity
Mots-clés : nano-biocomposite, antitumor effect. 
@article{NANO_2018_9_4_a13,
     author = {O. Shydlovska and E. Kharchenko and N. Zholobak and A. Shcherbakov and A. Marynin and O. Ivanova and A. Baranchikov and V. Ivanov},
     title = {Cerium oxide nanoparticles increase the cytotoxicity of {TNF-alpha} in vitro},
     journal = {Nanosistemy: fizika, himi\^a, matematika},
     pages = {537--543},
     publisher = {mathdoc},
     volume = {9},
     number = {4},
     year = {2018},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/NANO_2018_9_4_a13/}
}
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AU  - A. Shcherbakov
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AU  - A. Baranchikov
AU  - V. Ivanov
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%A A. Baranchikov
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O. Shydlovska; E. Kharchenko; N. Zholobak; A. Shcherbakov; A. Marynin; O. Ivanova; A. Baranchikov; V. Ivanov. Cerium oxide nanoparticles increase the cytotoxicity of TNF-alpha in vitro. Nanosistemy: fizika, himiâ, matematika, Tome 9 (2018) no. 4, pp. 537-543. http://geodesic.mathdoc.fr/item/NANO_2018_9_4_a13/