Geodesic
Cytotoxicity analysis of gadolinium doped cerium oxide nanoparticles on human mesenchymal stem cells
Nanosistemy: fizika, himiâ, matematika, Tome 9 (2018) no. 3, pp. 430-438

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A complex analysis of cytotoxicity was performed for a nanodispersed sol of cerium dioxide doped with gadolinium (Ce$_{0.8}$Gd$_{0.2}$O$_{2-x}$) using a culture of mesenchymal stem cells. The absence of cyto- and genotoxicity over a wide range of concentrations ($10^{-5} - 10^{-9}$ M) was demonstrated. At that, the highest concentration of Ce$_{0.8}$Gd$_{0.2}$O$_{2-x}$ nanoparticles ($10^{-4}$ M) was found to slightly reduce the activity of intracellular dehydrogenase, yet not leading to the development of apoptosis and further cell death. The obtained results confirm a high degree of Ce$_{0.8}$Gd$_{0.2}$O$_{2-x}$ nanoparticle biocompatibility, which opens prospects for their safe application as a contrasting agent in the magnetic resonance tomography.
Keywords: ceria, gadolinium, nanomaterials, cytotoxicity, mesenchymal stem cells. 
@article{NANO_2018_9_3_a16,
     author = {A. L. Popov and I. V. Savintseva and E. A. Mysina and A. B. Shcherbakov and N. R. Popova and O. S. Ivanova and D. D. Kolmanovich and V. K. Ivanov},
     title = {Cytotoxicity analysis of gadolinium doped cerium oxide nanoparticles on human mesenchymal stem cells},
     journal = {Nanosistemy: fizika, himi\^a, matematika},
     pages = {430--438},
     publisher = {mathdoc},
     volume = {9},
     number = {3},
     year = {2018},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/NANO_2018_9_3_a16/}
}
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AU  - D. D. Kolmanovich
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%A A. B. Shcherbakov
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%A O. S. Ivanova
%A D. D. Kolmanovich
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%J Nanosistemy: fizika, himiâ, matematika
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A. L. Popov; I. V. Savintseva; E. A. Mysina; A. B. Shcherbakov; N. R. Popova; O. S. Ivanova; D. D. Kolmanovich; V. K. Ivanov. Cytotoxicity analysis of gadolinium doped cerium oxide nanoparticles on human mesenchymal stem cells. Nanosistemy: fizika, himiâ, matematika, Tome 9 (2018) no. 3, pp. 430-438. http://geodesic.mathdoc.fr/item/NANO_2018_9_3_a16/