Geodesic
Antibacterial activity of Amikacin-immobilized detonation nanodiamond
Nanosistemy: fizika, himiâ, matematika, Tome 8 (2017) no. 4, pp. 531-534 Cet article a éte moissonné depuis la source Math-Net.Ru

Voir la notice de l'article

Detonation nanodiamonds (NDs) with chlorinated (ND-Cl) and carboxylated (ND-COOH) surfaces were obtained. The broad-spectrum antibiotic Amikacin (Amik) was covalently grafted to the chlorinated surface (ND-Amik) and immobilized by adsorption to carboxylated surface (Amik/ND-COOH). Biological testing in vitro showed the presence of antibacterial activity of the obtained samples against Staphylococcus aureus FDA P209 and Escherichia coli ATCC 25922, close to activity of free amikacin. It was revealed that to maintain antibacterial activity of the samples after their preliminary treatment, important factors such as the use of antioxidants (hydrosulfite and sodium citrate) and lyophilization were necessary.
Keywords: detonation nanodiamond (ND), amikacin (Amik), lyophilization, antioxidants, antibacterial activity. 
@article{NANO_2017_8_4_a14,
     author = {A. S. Solomatin and R. Yu. Yakovlev and O. V. Efremenkova and I. G. Sumarukova and I. I. Kulakova and G. V. Lisichkin},
     title = {Antibacterial activity of {Amikacin-immobilized} detonation nanodiamond},
     journal = {Nanosistemy: fizika, himi\^a, matematika},
     pages = {531--534},
     year = {2017},
     volume = {8},
     number = {4},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/NANO_2017_8_4_a14/}
}
TY  - JOUR
AU  - A. S. Solomatin
AU  - R. Yu. Yakovlev
AU  - O. V. Efremenkova
AU  - I. G. Sumarukova
AU  - I. I. Kulakova
AU  - G. V. Lisichkin
TI  - Antibacterial activity of Amikacin-immobilized detonation nanodiamond
JO  - Nanosistemy: fizika, himiâ, matematika
PY  - 2017
SP  - 531
EP  - 534
VL  - 8
IS  - 4
UR  - http://geodesic.mathdoc.fr/item/NANO_2017_8_4_a14/
LA  - en
ID  - NANO_2017_8_4_a14
ER  - 
%0 Journal Article
%A A. S. Solomatin
%A R. Yu. Yakovlev
%A O. V. Efremenkova
%A I. G. Sumarukova
%A I. I. Kulakova
%A G. V. Lisichkin
%T Antibacterial activity of Amikacin-immobilized detonation nanodiamond
%J Nanosistemy: fizika, himiâ, matematika
%D 2017
%P 531-534
%V 8
%N 4
%U http://geodesic.mathdoc.fr/item/NANO_2017_8_4_a14/
%G en
%F NANO_2017_8_4_a14
A. S. Solomatin; R. Yu. Yakovlev; O. V. Efremenkova; I. G. Sumarukova; I. I. Kulakova; G. V. Lisichkin. Antibacterial activity of Amikacin-immobilized detonation nanodiamond. Nanosistemy: fizika, himiâ, matematika, Tome 8 (2017) no. 4, pp. 531-534. http://geodesic.mathdoc.fr/item/NANO_2017_8_4_a14/