Geodesic
Toward Paclitaxel-[60]fullerene immunoconjugates as a targeted prodrug against cancer
Nanosistemy: fizika, himiâ, matematika, Tome 5 (2014) no. 1, pp. 67-75.

Voir la notice de l'article provenant de la source Math-Net.Ru

Two newly synthesized water-soluble conjugates of Paclitaxel with malonodiserinolamide-derivatized [60]fullerene (C$_{60}$-ser) undergo hydrolysis and release their medical payload under biological conditions. In vivo testing of one of these compounds in a murine model showed tumor volume reduction similar to the FDA-approved drug Abraxane, but without the associated weight-loss, indicating better tolerance of this new formulation.
Keywords: fullerene, immunoconjugate.
Mots-clés : Paclitaxel, cancer 
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     author = {Yu. Mackeyev and M. Raoof and B. Cisneros and N. Koshkina and C. S. Berger and L. J. Wilson and S. A. Curley},
     title = {Toward {Paclitaxel-[60]fullerene} immunoconjugates as a targeted prodrug against cancer},
     journal = {Nanosistemy: fizika, himi\^a, matematika},
     pages = {67--75},
     publisher = {mathdoc},
     volume = {5},
     number = {1},
     year = {2014},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/NANO_2014_5_1_a6/}
}
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Yu. Mackeyev; M. Raoof; B. Cisneros; N. Koshkina; C. S. Berger; L. J. Wilson; S. A. Curley. Toward Paclitaxel-[60]fullerene immunoconjugates as a targeted prodrug against cancer. Nanosistemy: fizika, himiâ, matematika, Tome 5 (2014) no. 1, pp. 67-75. http://geodesic.mathdoc.fr/item/NANO_2014_5_1_a6/