Experimental and Theoretical Methods of Study of Ionic Channels

D. A. Turchenkov ; V. S. Bystrov

Matematičeskaâ biologiâ i bioinformatika, Tome 9 (2014) no. 1, pp. 112-148.

Résumé

This work realizes the review of major types and properties of ion channels, experimental and theoretical approaches and models of describing their function. Voltage-clamp and patch-clamp methods with their configuration are considered, special attention given to mathematical models of ion channels and application of molecular dynamics, Brownian dynamic simulation, Poisson–Nernst–Planck equation and modern combined approaches. Ab initio methods of quantum chemistry are presented by DFT. Application conditions for each of these methodologies with their advantages and disadvantages are represented.

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