Reduction of the model of CD95-induced apoptosis
Matematičeskaâ biologiâ i bioinformatika, Tome 7 (2012) no. 1, pp. 139-151.

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Using the model of CD95-induced apoptosis regulation and systematic model reduction methodology implemented in the BioUML software, this paper demonstrates that the model can be approximated by a much smaller model without affecting its dynamics. This approach significantly simplifies the process of the complex biological systems modeling and expands the scope of research in silico. The results will be used to optimize the complex modular model of apoptosis including CD95 receptor signaling pathway.
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     author = {E. O. Kutumova},
     title = {Reduction of the model of {CD95-induced} apoptosis},
     journal = {Matemati\v{c}eska\^a biologi\^a i bioinformatika},
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     url = {http://geodesic.mathdoc.fr/item/MBB_2012_7_1_a0/}
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E. O. Kutumova. Reduction of the model of CD95-induced apoptosis. Matematičeskaâ biologiâ i bioinformatika, Tome 7 (2012) no. 1, pp. 139-151. http://geodesic.mathdoc.fr/item/MBB_2012_7_1_a0/

[1] MacFarlane M., Williams A.C., “Apoptosis and disease: a life or death decision”, EMBO Rep., 5 (2004), 674–678 | DOI

[2] Krammer P.H., Rudiger A., Lavrik I.N., “Life and death in peripheral T cells”, Nature Reviews Immunology, 7 (2007), 532–542 | DOI

[3] Bentele M., Lavrik I., Ulrich M., Sto?er S., Heermann D.W., Kalthoff H., Krammer P.H., Eils R., “Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis”, J. Cell Biol., 166:6 (2004), 839–851 | DOI

[4] Gorban A.N., Radulescu O., Zinovyev A.Y., “Asymptotology of Chemical Reaction Networks”, Chem. Eng. Sci., 65 (2009), 2310–2324

[5] Choi J., Yang K.W., Lee T.Y., Lee S.Y., “New time-scale criteria for model simplification of bio-reaction systems”, BMC Bioinformatics, 9 (2008), 338 | DOI

[6] Quaiser T., Dittrich A., Schaper F., Monnigmann M., “A simple workflow for biologically inspired model reduction — application to early JAK-STAT signaling”, BMC Systems Biology, 5 (2011), 30 | DOI

[7] Schilling M., Maiwald T., Hengl S., Winter D., Kreutz C., Kolch W., Lehmann W. D., Timmer J., Klingmuller U., “Theoretical and experimental analysis links isoform-specific ERK signaling to cell fate decisions”, Molecular Systems Biology, 5 (2009), 334 | DOI