Geodesic
Structure determination of the Pb$^{2+}$-specific GT aptamer using SAXS and molecular modeling methods
Žurnal Sibirskogo federalʹnogo universiteta. Matematika i fizika, Tome 17 (2024) no. 6, pp. 808-816

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Aptamer GT conjugated with gold nanoparticles is specific for heavy metal ions and can be used for water quality control and environmental monitoring. Circular dichroism (CD) and small-angle X-ray scattering (SAXS) measurements were performed to determine the structure of the aptamer complex with lead (II) ions. Comparison of the measurement results with different options of the spatial structure of the complexes obtained using molecular modeling allowed us to determine how the aptamer changes its conformation due to interacting with the target.
Keywords: aptamers, heavy metal ions, small-angle X-ray scattering, circular dichroism spectroscopy, molecular modeling. 
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     author = {Polina V. Artyushenko and Irina A. Shchugoreva and Anna N. Berlina and Nadezhda S. Komova and Kseniya V. Serebrennikova and Roman V. Moryachkov and Vladimir N. Zabluda and Alexey E. Sokolov and Felix N. Tomilin and Anna S. Kichkailo},
     title = {Structure determination of the {Pb}$^{2+}$-specific {GT} aptamer using {SAXS} and molecular modeling methods},
     journal = {\v{Z}urnal Sibirskogo federalʹnogo universiteta. Matematika i fizika},
     pages = {808--816},
     publisher = {mathdoc},
     volume = {17},
     number = {6},
     year = {2024},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/JSFU_2024_17_6_a13/}
}
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%A Polina V. Artyushenko
%A Irina A. Shchugoreva
%A Anna N. Berlina
%A Nadezhda S. Komova
%A Kseniya V. Serebrennikova
%A Roman V. Moryachkov
%A Vladimir N. Zabluda
%A Alexey E. Sokolov
%A Felix N. Tomilin
%A Anna S. Kichkailo
%T Structure determination of the Pb$^{2+}$-specific GT aptamer using SAXS and molecular modeling methods
%J Žurnal Sibirskogo federalʹnogo universiteta. Matematika i fizika
%D 2024
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%I mathdoc
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%F JSFU_2024_17_6_a13
Polina V. Artyushenko; Irina A. Shchugoreva; Anna N. Berlina; Nadezhda S. Komova; Kseniya V. Serebrennikova; Roman V. Moryachkov; Vladimir N. Zabluda; Alexey E. Sokolov; Felix N. Tomilin; Anna S. Kichkailo. Structure determination of the Pb$^{2+}$-specific GT aptamer using SAXS and molecular modeling methods. Žurnal Sibirskogo federalʹnogo universiteta. Matematika i fizika, Tome 17 (2024) no. 6, pp. 808-816. http://geodesic.mathdoc.fr/item/JSFU_2024_17_6_a13/