Geodesic
Existence of periodic solutions in the modified wheldon model of CML
Electronic journal of differential equations, Tome 2013 (2013)
The Wheldon model (1975) of a chronic myelogenous leukemia (CML) dynamics is modified and enriched by introduction of a time-varying microenvironment and time-dependent drug efficacies. The resulting model is a special class of nonautonomous nonlinear system of differential equations with delays. Via topological methods, the existence of positive periodic solutions is proven.
Classification : 34K20, 92D25, 34K45, 34K12, 34K25
Keywords: nonlinear nonautonomous delay differential equation, positive periodic solution, Leray-Schauder degree, chronic myelogenous leukemia, model with pharmacokinetics 
@article{EJDE_2013__2013__a45,
     author = {Amster,  Pablo and Balderrama,  Rocio and Idels,  Lev},
     title = {Existence of periodic solutions in the modified wheldon model of {CML}},
     journal = {Electronic journal of differential equations},
     year = {2013},
     volume = {2013},
     zbl = {1288.34077},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/EJDE_2013__2013__a45/}
}
TY  - JOUR
AU  - Amster,  Pablo
AU  - Balderrama,  Rocio
AU  - Idels,  Lev
TI  - Existence of periodic solutions in the modified wheldon model of CML
JO  - Electronic journal of differential equations
PY  - 2013
VL  - 2013
UR  - http://geodesic.mathdoc.fr/item/EJDE_2013__2013__a45/
LA  - en
ID  - EJDE_2013__2013__a45
ER  - 
%0 Journal Article
%A Amster,  Pablo
%A Balderrama,  Rocio
%A Idels,  Lev
%T Existence of periodic solutions in the modified wheldon model of CML
%J Electronic journal of differential equations
%D 2013
%V 2013
%U http://geodesic.mathdoc.fr/item/EJDE_2013__2013__a45/
%G en
%F EJDE_2013__2013__a45
Amster,  Pablo; Balderrama,  Rocio; Idels,  Lev. Existence of periodic solutions in the modified wheldon model of CML. Electronic journal of differential equations, Tome 2013 (2013). http://geodesic.mathdoc.fr/item/EJDE_2013__2013__a45/