Geodesic
Existence of periodic solutions in the modified wheldon model of CML
Electronic journal of differential equations, Tome 2013 (2013)
The Wheldon model (1975) of a chronic myelogenous leukemia (CML) dynamics is modified and enriched by introduction of a time-varying microenvironment and time-dependent drug efficacies. The resulting model is a special class of nonautonomous nonlinear system of differential equations with delays. Via topological methods, the existence of positive periodic solutions is proven.
Classification : 34K20, 92D25, 34K45, 34K12, 34K25
Keywords: nonlinear nonautonomous delay differential equation, positive periodic solution, Leray-Schauder degree, chronic myelogenous leukemia, model with pharmacokinetics 
@article{EJDE_2013__2013__a145,
     author = {Amster,  Pablo and Balderrama,  Rocio and Idels,  Lev},
     title = {Existence of periodic solutions in the modified wheldon model of {CML}},
     journal = {Electronic journal of differential equations},
     year = {2013},
     volume = {2013},
     zbl = {1288.34077},
     language = {en},
     url = {http://geodesic.mathdoc.fr/item/EJDE_2013__2013__a145/}
}
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Amster,  Pablo; Balderrama,  Rocio; Idels,  Lev. Existence of periodic solutions in the modified wheldon model of CML. Electronic journal of differential equations, Tome 2013 (2013). http://geodesic.mathdoc.fr/item/EJDE_2013__2013__a145/