Geodesic
CpG islands’ clustering uncovers early development genes in the human genome
Computer Science and Information Systems, Tome 15 (2018) no. 2
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We address the problem of the annotation of CpG islands (CGIs) clusters in the human genome. Upon analyzing gene content within CGIs clusters, piRNA, tRNA, and miRNA-encoding genes were found as well as CpG-rich homeobox genes reported previously. Chromosome-wide CGI density is positively correlated with replication timing, confirming that CGIs may serve as open chromatin markers. Early embryonic stage expressed KRAB-ZNF genes abundant at chromosome 19 were found to be interlinked with CGI clusters. We detected that a number of long CGIs and CGI clusters are, in fact, tandem copies with multiple annotated macrosatellites and paralogous genes. This finding implies that tandem expansion of CGIs may serve as a substrate for non-homologous recombination events.
Keywords: CpG islands, bioinformatics, human genome, macrosatellite, genome annotation, genome repeats, DNA methylation 
@article{CSIS_2018_15_2_a10,
     author = {Vladimir N. Babenko and Anton G. Bogomolov and Roman O. Babenko and Elvira R. Galieva and Yuriy L. Orlov},
     title = {CpG islands{\textquoteright} clustering uncovers early development genes in the human genome},
     journal = {Computer Science and Information Systems},
     year = {2018},
     volume = {15},
     number = {2},
     url = {http://geodesic.mathdoc.fr/item/CSIS_2018_15_2_a10/}
}
TY  - JOUR
AU  - Vladimir N. Babenko
AU  - Anton G. Bogomolov
AU  - Roman O. Babenko
AU  - Elvira R. Galieva
AU  - Yuriy L. Orlov
TI  - CpG islands’ clustering uncovers early development genes in the human genome
JO  - Computer Science and Information Systems
PY  - 2018
VL  - 15
IS  - 2
UR  - http://geodesic.mathdoc.fr/item/CSIS_2018_15_2_a10/
ID  - CSIS_2018_15_2_a10
ER  - 
%0 Journal Article
%A Vladimir N. Babenko
%A Anton G. Bogomolov
%A Roman O. Babenko
%A Elvira R. Galieva
%A Yuriy L. Orlov
%T CpG islands’ clustering uncovers early development genes in the human genome
%J Computer Science and Information Systems
%D 2018
%V 15
%N 2
%U http://geodesic.mathdoc.fr/item/CSIS_2018_15_2_a10/
%F CSIS_2018_15_2_a10
Vladimir N. Babenko; Anton G. Bogomolov; Roman O. Babenko; Elvira R. Galieva; Yuriy L. Orlov. CpG islands’ clustering uncovers early development genes in the human genome. Computer Science and Information Systems, Tome 15 (2018) no. 2. http://geodesic.mathdoc.fr/item/CSIS_2018_15_2_a10/