Three examples of a ground-breaking impact of the variable neighborhood search on investigations in graph theory
Bulletin de l'Académie serbe des sciences. Classe des sciences mathématiques et naturelles, Tome 41 (2016) no. 1.

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The well known computer package {c AutoGraphiX} $($AGX$)$ uses the variable neighborhood search to solve extremal problems in graph theory. We describe how AGX, in its very first application $($cf. G. Caporossi, et al. $[$J. Chem. Inform. Comp. Sci. {\bf39} {\rm (1999), 984--996])}, has influenced substantially the study of graph energy. AGX helped very much in creating the spectral graph theory based on the signless Laplacian (see D. Cvetković, et al. $[$Publ. Inst. Math. $($Beograd$)$ {\bf81 (95)} {\rm (2007), 11--27])} and created some non-trivial conjectures on the largest eigenvalue of a graph (see M. Aouchiche, et al. $[$Europ. J. Oper. Res. {\bf 191} {\rm(3) (2008), 661--676])}
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     title = {Three examples of a ground-breaking impact of the variable neighborhood search on investigations in graph theory},
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Dragoš Cvetković. Three examples of a ground-breaking impact of the variable neighborhood search on investigations in graph theory. Bulletin de l'Académie serbe des sciences. Classe des sciences mathématiques et naturelles, Tome 41 (2016) no. 1. http://geodesic.mathdoc.fr/item/BASS_2016_41_1_a3/