Geodesic
Genetic and Tabu search algorithms for peptide assembly problem
RAIRO - Operations Research - Recherche Opérationnelle, Tome 44 (2010) no. 2, pp. 153-166

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Determining amino acid sequences of protein molecules is one of the most important issues in molecular biology. These sequences determine protein structure and functionality. Unfortunately, direct biochemical methods for reading amino acid sequences can be used for reading short sequences only. This is the reason, which makes peptide assembly algorithms an important complement of these methods. In this paper, a genetic algorithm solving the problem of short amino acid sequence assembly is presented. The algorithm has been tested in computational experiment and compared with an existing tabu search method for the same problem. The results clearly show that the genetic algorithm outperformed the tabu search approach.

DOI : 10.1051/ro/2010012
Classification : 92D20
Keywords: peptide sequencing, combinatorial optimization problem, genetic algorithm, tabu search algorithm 
@article{RO_2010__44_2_153_0,
     author = {B{\l}a\.zewicz, Jacek and Borowski, Marcin and Formanowicz, Piotr and G{\l}owacki, Tomasz},
     title = {Genetic and {Tabu} search algorithms for peptide assembly problem},
     journal = {RAIRO - Operations Research - Recherche Op\'erationnelle},
     pages = {153--166},
     publisher = {EDP-Sciences},
     volume = {44},
     number = {2},
     year = {2010},
     doi = {10.1051/ro/2010012},
     zbl = {1187.92036},
     language = {en},
     url = {http://geodesic.mathdoc.fr/articles/10.1051/ro/2010012/}
}
TY  - JOUR
AU  - Błażewicz, Jacek
AU  - Borowski, Marcin
AU  - Formanowicz, Piotr
AU  - Głowacki, Tomasz
TI  - Genetic and Tabu search algorithms for peptide assembly problem
JO  - RAIRO - Operations Research - Recherche Opérationnelle
PY  - 2010
SP  - 153
EP  - 166
VL  - 44
IS  - 2
PB  - EDP-Sciences
UR  - http://geodesic.mathdoc.fr/articles/10.1051/ro/2010012/
DO  - 10.1051/ro/2010012
LA  - en
ID  - RO_2010__44_2_153_0
ER  - 
%0 Journal Article
%A Błażewicz, Jacek
%A Borowski, Marcin
%A Formanowicz, Piotr
%A Głowacki, Tomasz
%T Genetic and Tabu search algorithms for peptide assembly problem
%J RAIRO - Operations Research - Recherche Opérationnelle
%D 2010
%P 153-166
%V 44
%N 2
%I EDP-Sciences
%U http://geodesic.mathdoc.fr/articles/10.1051/ro/2010012/
%R 10.1051/ro/2010012
%G en
%F RO_2010__44_2_153_0
Błażewicz, Jacek; Borowski, Marcin; Formanowicz, Piotr; Głowacki, Tomasz. Genetic and Tabu search algorithms for peptide assembly problem. RAIRO - Operations Research - Recherche Opérationnelle, Tome 44 (2010) no. 2, pp. 153-166. doi: 10.1051/ro/2010012

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