Towards stresses and strains in the respiratory system
ESAIM. Proceedings, Tome 23 (2008), pp. 98-113
Cet article a éte moissonné depuis la source EDP Sciences
This paper is concerned with coupled problems in the human respiratory system with emphasis on mechanical ventilation. We focus on the modeling aspects of pulmonary alveoli and the lower airways against the background of acute lung diseases. In this connection occurring stresses and strains are of substantial interest.
For the first generations of the bronchial tree, a geometry based on human computer tomography scans obtained from in-vivo experiments is employed. The deformability of airway walls is taken into account to study airflow structures and airway wall stresses for a number of different scenarios. Therefore we carried out fluid-structure interaction (FSI) simulations under transient incompressible flow conditions. Both models for healthy and diseased lungs are studied under normal breathing as well as under mechanical ventilation.
Our alveolar model is based on three-dimensional artificial random geometries generated with the help of a new labyrinthine algorithm ensuring preservation of overall minimal mean pathlength. A polyconvex hyperelastic material model incorporating general histologic information is employed to realistically describe alveolar parenchymal tissue properties. The influence of surface-active agents (the so-called surfactant) on the overall mechanical behavior of pulmonary alveoli is investigated. For this purpose an adsorption-limited model relating surface stresses to the interfacial concentration of surfactant is used.
Affiliations des auteurs :
Lena Wiechert 1 ; Timon Rabczuk 1, 2 ; Andrew Comerford 1 ; Robert Metzke 1 ; Wolfgang A. Wall 1
@article{EP_2008_23_a7,
author = {Lena Wiechert and Timon Rabczuk and Andrew Comerford and Robert Metzke and Wolfgang A. Wall},
title = {Towards stresses and strains in the respiratory system},
journal = {ESAIM. Proceedings},
pages = {98--113},
year = {2008},
volume = {23},
doi = {10.1051/proc:082307},
language = {en},
url = {http://geodesic.mathdoc.fr/articles/10.1051/proc:082307/}
}
TY - JOUR AU - Lena Wiechert AU - Timon Rabczuk AU - Andrew Comerford AU - Robert Metzke AU - Wolfgang A. Wall TI - Towards stresses and strains in the respiratory system JO - ESAIM. Proceedings PY - 2008 SP - 98 EP - 113 VL - 23 UR - http://geodesic.mathdoc.fr/articles/10.1051/proc:082307/ DO - 10.1051/proc:082307 LA - en ID - EP_2008_23_a7 ER -
%0 Journal Article %A Lena Wiechert %A Timon Rabczuk %A Andrew Comerford %A Robert Metzke %A Wolfgang A. Wall %T Towards stresses and strains in the respiratory system %J ESAIM. Proceedings %D 2008 %P 98-113 %V 23 %U http://geodesic.mathdoc.fr/articles/10.1051/proc:082307/ %R 10.1051/proc:082307 %G en %F EP_2008_23_a7
Lena Wiechert; Timon Rabczuk; Andrew Comerford; Robert Metzke; Wolfgang A. Wall. Towards stresses and strains in the respiratory system. ESAIM. Proceedings, Tome 23 (2008), pp. 98-113. doi: 10.1051/proc:082307
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