A mixture model for the dynamic of the gut mucus layer
ESAIM. Proceedings, Tome 55 (2016), pp. 111-130
Cet article a éte moissonné depuis la source EDP Sciences
We introduce a mixture model intended to describe the dynamics of the mucus layer that wraps the gut mucosa. This model takes into account the fluid mechanics of the gut content, the inhomogeneous rheology that depends on the fluid composition, and the main physiological mechanisms that ensure the homoeostasis of the mucus layer. Numerical simulations, based on a finite volume approach, prove the ability of the model to produce a stable steady-state mucus layer. We also perform a sensitivity analysis by using a meta-model based on polynomial chaos in order to identify the main parameters impacting the shape of the mucus layer. The effect of the interaction of the mucus with a population of bacteria is eventually discussed.
Affiliations des auteurs :
Tamara El Bouti 1 ; Thierry Goudon 2 ; Simon Labarthe 3 ; Béatrice Laroche 3 ; Bastien Polizzi 2 ; Amira Rachah 4 ; Magali Ribot 5, 2 ; Rémi Tesson 6
@article{EP_2016_55_a6,
author = {Tamara El Bouti and Thierry Goudon and Simon Labarthe and B\'eatrice Laroche and Bastien Polizzi and Amira Rachah and Magali Ribot and R\'emi Tesson},
title = {A mixture model for the dynamic of the gut mucus layer},
journal = {ESAIM. Proceedings},
pages = {111--130},
year = {2016},
volume = {55},
doi = {10.1051/proc/201655111},
language = {en},
url = {http://geodesic.mathdoc.fr/articles/10.1051/proc/201655111/}
}
TY - JOUR AU - Tamara El Bouti AU - Thierry Goudon AU - Simon Labarthe AU - Béatrice Laroche AU - Bastien Polizzi AU - Amira Rachah AU - Magali Ribot AU - Rémi Tesson TI - A mixture model for the dynamic of the gut mucus layer JO - ESAIM. Proceedings PY - 2016 SP - 111 EP - 130 VL - 55 UR - http://geodesic.mathdoc.fr/articles/10.1051/proc/201655111/ DO - 10.1051/proc/201655111 LA - en ID - EP_2016_55_a6 ER -
%0 Journal Article %A Tamara El Bouti %A Thierry Goudon %A Simon Labarthe %A Béatrice Laroche %A Bastien Polizzi %A Amira Rachah %A Magali Ribot %A Rémi Tesson %T A mixture model for the dynamic of the gut mucus layer %J ESAIM. Proceedings %D 2016 %P 111-130 %V 55 %U http://geodesic.mathdoc.fr/articles/10.1051/proc/201655111/ %R 10.1051/proc/201655111 %G en %F EP_2016_55_a6
Tamara El Bouti; Thierry Goudon; Simon Labarthe; Béatrice Laroche; Bastien Polizzi; Amira Rachah; Magali Ribot; Rémi Tesson. A mixture model for the dynamic of the gut mucus layer. ESAIM. Proceedings, Tome 55 (2016), pp. 111-130. doi: 10.1051/proc/201655111
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