Geodesic
Model-based Comparison of Cell Density-dependent Cell Migration Strategies
H. Hatzikirou1 ; K. Böttger2 ; A. Deutsch2
1 Center for Advancing Electronics Dresden, Technische Universität Dresden, 01062 Dresden, Germany
2 Center for Information Services and High-Performance Computing, Technische Universität Dresden, 01062 Dresden, Germany
Mathematical modelling of natural phenomena, Tome 10 (2015) no. 1, pp. 94-107.

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Here, we investigate different cell density-dependent migration strategies. In particular, we consider strategies which differ in the precise regulation of transitions between resting and motile phenotypes. We develop a lattice-gas cellular automaton (LGCA) model for each migration strategy. Using a mean-field approximation we quantify the corresponding spreading dynamics at the cell population level. Our results allow for the prediction of cell population spreading based on experimentally accessible single cell migration parameters.
DOI : 10.1051/mmnp/201510105

H. Hatzikirou 1 ; K. Böttger 2 ; A. Deutsch 2

1 Center for Advancing Electronics Dresden, Technische Universität Dresden, 01062 Dresden, Germany
2 Center for Information Services and High-Performance Computing, Technische Universität Dresden, 01062 Dresden, Germany 
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H. Hatzikirou; K. Böttger; A. Deutsch. Model-based Comparison of Cell Density-dependent Cell Migration Strategies. Mathematical modelling of natural phenomena, Tome 10 (2015) no. 1, pp. 94-107. doi : 10.1051/mmnp/201510105. http://geodesic.mathdoc.fr/articles/10.1051/mmnp/201510105/

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